ArticleThe Journal of cell biology1996
Protein kinase C mu is located at the Golgi compartment.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 104 citations in OpenAlex.
- Membrane trafficking in breast cancer progression: protein kinase D comes into play.Frontiers in cell and developmental biology · 2023Review
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- Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases.Biomolecules · 2021Review
- Subtilase cytotoxin produced by locus of enterocyte effacement-negative Shiga-toxigenic Escherichia coli induces stress granule formation.Cellular microbiology · 2016Article
- Rab5c promotes AMAP1-PRKD2 complex formation to enhance β1 integrin recycling in EGF-induced cancer invasion.The Journal of cell biology · 2012Article
- Context-dependent activation kinetics elicited by soluble versus outer membrane vesicle-associated heat-labile enterotoxin.Infection and immunity · 2011Article
- Article
- Novel function of cardiac protein kinase D1 as a dynamic regulator of Ca2+ sensitivity of contraction.The Journal of biological chemistry · 2010Article
- Regulation of Golgi structure and secretion by receptor-induced G protein βγ complex translocation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C.American journal of physiology. Renal physiology · 2009Article
- Remodeling of the Golgi structure by ERK signaling.Communicative & integrative biology · 2009Article
- Transient dynamic actin cytoskeletal change stimulates the osteoblastic differentiation.Journal of bone and mineral metabolism · 2009Article
- Protein kinase D1: a new component in TLR9 signaling.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- PKD1, PKD2, and their substrate Kidins220 regulate neurotensin secretion in the BON human endocrine cell line.The Journal of biological chemistry · 2008Article
- Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway.Molecular biology of the cell · 2007Article
- Protein kinase D regulates vesicular transport by phosphorylating and activating phosphatidylinositol-4 kinase IIIbeta at the Golgi complex.Nature cell biology · 2005Article
- Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through Akt.The Biochemical journal · 2002Article
- Structural requirements for localization and activation of protein kinase C mu (PKC mu) at the Golgi compartment.The Journal of cell biology · 2002Article
- Recruitment of protein kinase D to the trans-Golgi network via the first cysteine-rich domain.The EMBO journal · 2001Article
- The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptors.The Journal of experimental medicine · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein kinase C mu (PKC mu) displays unusual structural features like a pleckstrin homology domain and an amino-terminal hydrophobic region with a putative leader peptide and transmembrane sequence. As a discrete location often is a direct clue to the potential biological function of a kinase, antibodies directed against unique amino- and carboxy-terminal domains of PKC mu were used to localize the protein within intracellular compartments in immunofluorescence and subcellular fractionation studies. Confocal laser scanning microscopy showed colocalization of PKC mu with the resident Golgi marker protein beta 1,4 galactosyltransferase in PKC mu transfectants and in the human hepatocellular carcinoma cell line HepG2, expressing endogenous PKC mu. Long-term treatment of cells with brefeldin A, which disintegrates the Golgi apparatus, disrupted PKC mu-specific staining. Cosegregation of PKC mu with beta 1,4 galactosyltransferase, but not with the endosomal marker rab5, upon density gradient fractionation and Western blot analysis of HepG2 cell extracts, provides independent evidence for a Golgi localization of PKC mu. Moreover, cellular sulfate uptake and Golgi-specific glycosaminoglycan sulfation was enhanced in PKC mu transfectants. Together, these data suggest that PKC mu is a resident protein kinase of the core Golgi compartment and is involved in basal transport processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.