ArticleBreast cancer research and treatment1996
Characterization of the estrogen receptor transfected MCF10A breast cell line 139B6.
Article in Breast cancer research and treatment, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 49 citations in OpenAlex.
- Acetyl-11-keto-β-boswellic Acid Inhibits Precancerous Breast Lesion MCF-10AT Cells via Regulation of LINC00707/miR-206 that Reduces Estrogen Receptor-α.Cancer management and research · 2020Article
- Effects of phthalates on normal human breast cells co-cultured with different fibroblasts.PloS one · 2018Article
- Activity of EGFR, mTOR and PI3K inhibitors in an isogenic breast cell line model.BMC research notes · 2014Article
- GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast.Hormones & cancer · 2014Article
- Role of ERRF, a novel ER-related nuclear factor, in the growth control of ER-positive human breast cancer cells.The American journal of pathology · 2012Article
- TRIM29 functions as a tumor suppressor in nontumorigenic breast cells and invasive ER+ breast cancer.The American journal of pathology · 2012Article
- TARGETING THE GENOTOXIC EFFECTS OF ESTROGENS.Drug discovery today. Disease mechanisms · 2012Article
- Estrogens, regulation of p53 and breast cancer risk: a balancing act.Cellular and molecular life sciences : CMLS · 2010Review
- Anacardic acid inhibits estrogen receptor alpha-DNA binding and reduces target gene transcription and breast cancer cell proliferation.Molecular cancer therapeutics · 2010Article
- Estrogen induced breast cancer is the result in the disruption of the asymmetric cell division of the stem cell.Hormone molecular biology and clinical investigation · 2010Article
- Progesterone receptor A-regulated gene expression in mammary organoid cultures.The Journal of steroid biochemistry and molecular biology · 2009Article
- Tissue architecture and breast cancer: the role of extracellular matrix and steroid hormones.Endocrine-related cancer · 2000Review
- Estrogen responsiveness and control of normal human breast proliferation.Journal of mammary gland biology and neoplasia · 1998Review
- The Chinese Herbal Formula Ruyan Neixiao Cream Inhibits Angiogenesis of Precancerous Breast Lesions via Regulation of Ras/Raf/MEK/ERK Signaling Pathway.Integrative cancer therapiesArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
There has been increasing evidence which suggests that abnormal expression of the estrogen receptor (ER) protein in nonmalignant breast tissue may be important in the carcinogenic process. To examine the effects of ER expression in immortalized nonmalignant mammary epithelial cells, an expression vector containing human ER cDNA was transfected into the ER negative human breast cells, MCF10A. Characterization of a clone stably expressing ER, 139B6, provided evidence for the regulated synthesis of a functional ER capable of binding estradiol-17 beta (E2) and undergoing processing. Expression of the ER gene did not enable E2 to stimulate endogenous genes [progesterone receptor (PgR), pS2, cathepsin D and TGF alpha] which normally respond to estrogens in breast cancer cells. The ER in 139B6 cells was, however, capable of inducing expression of an ERE-regulated reporter gene, indicating its ability to interact with transcriptional machinery. Furthermore, cultures in log growth displayed a slight increase in doubling time in the presence of E2. These results indicate that ER expression alone is not sufficient to induce a transformed phenotype. Thus, the 139B6 cell line should provide a new model for determining what additional changes lead to increased growth potential in response to E2 and for exploring how E2 itself may help bring about changes leading to progression of preneoplastic breast epithelial cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.