ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Density-dependent feedback inhibition of oligodendrocyte precursor expansion.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed.
- Review
- Oligodendroglia and Myelin: Supporting the Connectome.Advances in neurobiology · 2025Review
- A New Acquaintance of Oligodendrocyte Precursor Cells in the Central Nervous System.Neuroscience bulletin · 2024Review
- Overexpression of bone morphogenetic protein 7 reduces oligodendrocytes loss and promotes functional recovery after spinal cord injury.Journal of cellular and molecular medicine · 2021Article
- Oligodendrocyte progenitors as environmental biosensors.Seminars in cell & developmental biology · 2021Review
- Review
- Modeling the dynamics of oligodendrocyte precursor cells and the genesis of gliomas.PLoS computational biology · 2018Article
- Embracing oligodendrocyte diversity in the context of perinatal injury.Neural regeneration research · 2017Review
- The reactions and role of NG2 glia in spinal cord injury.Brain research · 2016Review
- How to make an oligodendrocyte.Development (Cambridge, England) · 2015Review
- All brains are made of this: a fundamental building block of brain matter with matching neuronal and glial masses.Frontiers in neuroanatomy · 2014Article
- Cyclin dependent kinase 5 is required for the normal development of oligodendrocytes and myelin formation.Developmental biology · 2013Article
- Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain.Nature neuroscience · 2013Article
- Quantitative microplate assay for studying mesenchymal stromal cell-induced neuropoiesis.Stem cells translational medicine · 2013Article
- Fbxw7 regulates Notch to control specification of neural precursors for oligodendrocyte fate.Neural development · 2012Article
- The curious case of NG2 cells: transient trend or game changer?ASN neuro · 2011Review
- Interactions between oligodendrocyte precursors control the onset of CNS myelination.Developmental biology · 2011Article
- The geometric and spatial constraints of the microenvironment induce oligodendrocyte differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Cellular scaling rules for primate brains.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Cellular scaling rules for rodent brains.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The myelin sheath in the vertebrate CNS is formed by oligodendrocytes. The number of oligodendrocytes in a mature axon tract must be sufficient to myelinate all appropriate axons. How the number of oligodendrocytes is matched to axonal requirements and whether such matching involves axon-oligodendrocyte signaling or intrinsic oligodendrocyte self-regulation are not clear. Using a combination of in vitro analyses, we demonstrate that oligodendrocyte precursors closely regulate their numbers through interactions between adjacent precursors. In low-density rat spinal cord cultures, the number of oligodendrocyte lineage cells increases rapidly. The addition of large numbers of oligodendrocyte precursors substantially reduces precursor expansion and results in a normalization of oligodendrocyte lineage cell numbers in the cultures over time. Thus, the number of oligodendrocyte lineage cells that develop appears dependent on the density of oligodendrocyte lineage cells. This normalization of cell number is reflected in assays of clonal potential and proliferation. For example, precursors gave rise to fewer progeny and proliferated less at high density. Reduced precursor expansion at high density was not attributable to the depletion of growth factors. Cocultures of high and low densities did not inhibit precursor expansion in low-density cultures, suggesting the requirement for local cell-cell interactions. The inhibition of precursor expansion was cell-type-specific and dependent on the presence of oligodendrocyte lineage cells. We propose that this density-dependent feedback inhibition of oligodendrocyte precursor expansion may play a primary role in regulating the number of oligodendrocytes in the developing spinal cord.
Indexed as
Identifiers
8824327PMC6579258What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.