ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Functional analysis of dynactin and cytoplasmic dynein in slow axonal transport.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 93 citations in OpenAlex.
- Dynein and dynactin move long-range but are delivered separately to the axon tip.The Journal of cell biology · 2024Article
- Polarity Sorting of Microtubules in the Axon.Trends in neurosciences · 2018Review
- Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin.The Journal of cell biology · 2017Article
- Article
- Local synthesis of dynein cofactors matches retrograde transport to acutely changing demands.Nature communications · 2016Article
- Article
- Distinct functional roles of cytoplasmic dynein defined by the intermediate chain isoforms.Experimental cell research · 2015Review
- Seeing the unseen: the hidden world of slow axonal transport.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2014Review
- Epidermal growth factor stimulates extracellular-signal regulated kinase phosphorylation of a novel site on cytoplasmic Dynein intermediate chain 2.International journal of molecular sciences · 2013Article
- Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Selective vulnerability of synaptic signaling and metabolism to nitrosative stress.Antioxidants & redox signaling · 2012Review
- Interaction with a kinesin-2 tail propels choline acetyltransferase flow towards synapse.Traffic (Copenhagen, Denmark) · 2012Article
- Are kinesins required for organelle trafficking in plant cells?Frontiers in plant science · 2012Article
- Phosphorylation regulates targeting of cytoplasmic dynein to kinetochores during mitosis.The Journal of cell biology · 2008Article
- A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes.The Journal of cell biology · 2008Article
- Cytoskeletal requirements in axonal transport of slow component-b.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Axonal dynactin p150Glued transports caspase-8 to drive retrograde olfactory receptor neuron apoptosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Role of cytoplasmic dynein in the axonal transport of microtubules and neurofilaments.The Journal of cell biology · 2005Article
- Role of actin filaments in the axonal transport of microtubules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Neurofilament transport is dependent on actin and myosin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuron moves protein and membrane from the cell body to the synapse and back via fast and slow axonal transport. Little is known about the mechanism of microtubule movement in slow axonal transport, although cytoplasmic dynein, the motor for retrograde fast axonal transport of membranous organelles, has been proposed to also slide microtubules down the axon. We previously showed that most of the cytoplasmic dynein moving in the anterograde direction in the axon is associated with the microfilaments and other proteins of the slow component b (SCb) transport complex. The dynactin complex binds dynein, and it has been suggested that dynactin also associates with microfilaments. We therefore examined the role of dynein and dynactin in slow axonal transport. We find that most of the dynactin is also transported in SCb, including dynactin, which contains the neuron-specific splice variant p135(Glued), which binds dynein but not microtubules. Furthermore, SCb dynein binds dynactin in vitro. SCb dynein, like dynein from brain, binds microtubules in an ATP-sensitive manner, whereas brain dynactin binds microtubules in a salt-dependent manner. Dynactin from SCb does not bind microtubules, indicating that the binding of dynactin to microtubules is regulated and suggesting that the role of SCb dynactin is to bind dynein, not microtubules. These data support a model in which dynactin links the cytoplasmic dynein to the SCb transport complex. Dynein then may interact transiently with microtubules to slide them down the axon at the slower rate of SCa.
Indexed as
Identifiers
8824315PMC6579239W1554617917What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.