ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Ryanodine-sensitive component of calcium transients evoked by nerve firing at presynaptic nerve terminals.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 87 citations in OpenAlex.
- LIM domain only 4 (LMO4) regulates calcium-induced calcium release and synaptic plasticity in the hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Understanding calcium waves and sparks in central neurons.Nature reviews. Neuroscience · 2012Review
- Transient receptor potential vanilloid subtype 1 channel mediated neuropeptide secretion and depressor effects: role of endoplasmic reticulum associated Ca2+ release receptors in rat dorsal root ganglion neurons.Journal of hypertension · 2008Article
- Use-dependent amplification of presynaptic Ca2+ signaling by axonal ryanodine receptors at the hippocampal mossy fiber synapse.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Bioluminescence imaging of mitochondrial Ca2+ dynamics in soma and neurites of individual adult mouse sympathetic neurons.The Journal of physiology · 2007Article
- Noradrenaline triggers multivesicular release at glutamatergic synapses in the hypothalamus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Synaptic mechanisms of persistent reverberatory activity in neuronal networks.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Presynaptic ryanodine-sensitive calcium stores contribute to evoked neurotransmitter release at the basket cell-Purkinje cell synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- The requirement of presynaptic metabotropic glutamate receptors for the maintenance of locomotion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Assessing the role of calcium-induced calcium release in short-term presynaptic plasticity at excitatory central synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Roles for mitochondrial and reverse mode Na+/Ca2+ exchange and the plasmalemma Ca2+ ATPase in post-tetanic potentiation at crayfish neuromuscular junctions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Multiple modes of calcium-induced calcium release in sympathetic neurons I: attenuation of endoplasmic reticulum Ca2+ accumulation at low [Ca2+](i) during weak depolarization.The Journal of general physiology · 2001Article
- The properties of ryanodine-sensitive Ca(2+) release in mouse gastric smooth muscle cells.British journal of pharmacology · 2001Article
- Differential regulation of transmitter release by presynaptic and glial Ca2+ internal stores at the neuromuscular synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Intensity-dependent, rapid activation of presynaptic metabotropic glutamate receptors at a central synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Origin sites of calcium release and calcium oscillations in frog sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Functional IP3- and ryanodine-sensitive calcium stores in presynaptic varicosities of NG108-15 (rodent neuroblastoma x glioma hybrid) cells.The Journal of physiology · 2000Article
- Release of dopamine from human neocortex nerve terminals evoked by different stimuli involving extra- and intraterminal calcium.British journal of pharmacology · 2000Article
- Dense-cored vesicles, smooth endoplasmic reticulum, and mitochondria are closely associated with non-specialized parts of plasma membrane of nerve terminals: implications for exocytosis and calcium buffering by intraterminal organelles.The Journal of comparative neurology · 1999Article
- A Ca2+-induced Ca2+ release mechanism involved in asynchronous exocytosis at frog motor nerve terminals.The Journal of general physiology · 1998Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Whether Ca2+ released from stores within the presynaptic nerve terminals also contributes to the Ca2+ elevation evoked by action potentials was tested in intact bullfrog sympathetic ganglia. Intraterminal Ca2+ transients (Delta[Ca2+]i) were evoked by electrical shocks to the presynaptic nerves at 20 Hz and were monitored by fura-2 fluorimetry. Ca2+ released through intraterminal ryanodine-sensitive channels accounted for 46% of the peak Ca2+ elevation. Moreover, in half of the terminals when intraterminal release was blocked by ryanodine, Delta[Ca2+]i reached a plateau at 200 +/- 24 nM. Because 20 Hz is a frequency favorable for the release of a neuropeptide, luteinizing hormone releasing hormone (LHRH) from these presynaptic nerve terminals, and because the threshold level for LHRH release is 186 nM, intraterminal Ca2+ release during nerve firing is likely to play a major role in regulating LHRH release. The intraterminal ryanodine channels were facilitated by caffeine as in other tissue. The releasable ryanodine-sensitive store could elevate the intraterminal [Ca2+] by an amount as high as 1.6 microM at a rate as fast as 250 nM/sec. The store could be refilled within 100 sec after a maximal discharge of its content by 20 Hz firing. Oscillation of [Ca2+]i evoked by 20 Hz nerve firing occurred in normal Ringer solution, in ryanodine, and in caffeine with a periodicity of approximately 10 sec. Besides the facilitatory effects on the ryanodine-sensitive channels, caffeine also had inhibitory effects on Delta[Ca2+]i via its action on a different process.
Indexed as
Identifiers
8824311PMC6579274W1788957748What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.