ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Cloning and functional expression of a Drosophila metabotropic glutamate receptor expressed in the embryonic CNS.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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Who cites it
42 citing papers in PubMed, 114 citations in OpenAlex.
- Combinatory Actions of Co-transmitters in Dopaminergic Systems ModulateThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- The Complex Formed by Group I Metabotropic Glutamate Receptor (mGluR) and Homer1a Plays a Central Role in Metaplasticity and Homeostatic Synaptic Scaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Genetic disruption of the putative binding site for Homer on DmGluRA reduces sleep in Drosophila.Sleep · 2020Article
- ON selectivity in theeLife · 2019Article
- Loss of DmGluRA exacerbates age-related sleep disruption and reduces lifespan.Neurobiology of aging · 2019Article
- A Presynaptic Function of Shank Protein inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Genetic interaction of DISC1 and Neurexin in the development of fruit fly glutamatergic synapses.NPJ schizophrenia · 2017Article
- The Amino Acid Transporter JhI-21 Coevolves with Glutamate Receptors, Impacts NMJ Physiology, and Influences Locomotor Activity in Drosophila Larvae.Scientific reports · 2016Article
- Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models.Frontiers in behavioral neuroscience · 2016Article
- Metabotropic Glutamate Receptors: MODULATORS OF CONTEXT-DEPENDENT FEEDING BEHAVIOUR IN C. ELEGANS.The Journal of biological chemistry · 2015Article
- Identification of Inhibitory Premotor Interneurons Activated at a Late Phase in a Motor Cycle during Drosophila Larval Locomotion.PloS one · 2015Article
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- Increasing our understanding of human cognition through the study of Fragile X Syndrome.Developmental neurobiology · 2014Review
- Agonist-dependent signaling by group I metabotropic glutamate receptors is regulated by association with lipid domains.The Journal of biological chemistry · 2013Article
- Glutamate is an inhibitory neurotransmitter in the Drosophila olfactory system.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Pharmacological reversal of synaptic plasticity deficits in the mouse model of fragile X syndrome by group II mGluR antagonist or lithium treatment.Brain research · 2011Article
- Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.PloS one · 2011Article
- A novel approach for in vivo screening of toxins using the Drosophila Giant Fiber circuit.Toxicon : official journal of the International Society on Toxinology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The excitatory neurotransmitter glutamate plays important roles in the mammalian brain, ranging from synaptic plasticity to memory. To mediate these functions, glutamate activates two types of receptors: ligand-gated channels and metabotropic receptors coupled to G-proteins. Both families of glutamate receptors share no sequence homology and possess original structural features compared with other ligand-gated channels and G-protein-coupled receptors, respectively. Glutamate-gated receptor-channel subunits have already been characterized in invertebrates. Here we report the cloning and functional characterization of an invertebrate metabotropic glutamate receptor (DmGluRA) isolated from Drosophila melanogaster. This receptor displays 45 and 43% amino acid sequence identity with its mammalian homologs mGluR3 and mGluR2, respectively. Moreover, its pharmacology and transduction mechanisms are surprisingly similar to those of mGluR2 and mGluR3. DmGluRA is expressed in the CNS of the late embryo. These results indicate that the original structural features of both glutamate receptor types are conserved from insects to mammals and suggest that the functions of these receptors have been highly conserved during evolution.
Indexed as
Identifiers
8824309PMC6579245W1576507987What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.