ArticleImmunogenetics1996
Molecular cloning and linkage analysis of the Japanese medaka fish complement Bf/C2 gene.
Article in Immunogenetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 69 citations in OpenAlex.
- Preliminary study of BF/C2 on immune mechanism of grass carp against GCRV infection.BMC genomics · 2024Article
- Characterization of C1q in teleosts: insight into the molecular and functional evolution of C1q family and classical pathway.The Journal of biological chemistry · 2010Article
- Identification and analysis of immune-related transcriptome in Asian seabass Lates calcarifer.BMC genomics · 2010Article
- Molecular characterization of the alpha subunit of complement component C8 (GcC8alpha) in the nurse shark (Ginglymostoma cirratum).Fish & shellfish immunology · 2009Article
- Genomic view of the evolution of the complement system.Immunogenetics · 2006Review
- A genome-wide survey of Major Histocompatibility Complex (MHC) genes and their paralogues in zebrafish.BMC genomics · 2005Article
- Complement C2 receptor inhibitor trispanning: from man to schistosome.Springer seminars in immunopathology · 2005Review
- Structure and the evolutionary implication of the triplicated complement factor B genes of a urochordate ascidian, Ciona intestinalis.Immunogenetics · 2005Article
- A detailed linkage map of medaka, Oryzias latipes: comparative genomics and genome evolution.Genetics · 2000Article
- Identification and mapping of two divergent, unlinked major histocompatibility complex class II B genes in Xiphophorus fishes.Genetics · 1998Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evolutionary studies of complement factor B (Bf) and C2 in lower vertebrates have revealed the presence of the Bf/C2 common ancestor-like molecule in lamprey (cyclostome) and the Bf molecule encoded by the duplicated genes closely linked to the major histocompatibility complex (MHC) in Xenopus (amphibian). To further define when Bf/C2 gene duplication occurred and when linkage between the Bf/C2 gene and the MHC was established, we amplified the Bf/C2 sequences in teleost, the Japanese medaka (Oryzias latipes), by reverse transcription - polymerase chain reaction with primers corresponding to the common amino acid sequences shared by mammalian Bf and C2. Only a single molecular species has been amplified, and the corresponding cDNA clones were isolated from the liver cDNA library. The longest insert contained 2384 nucleotides with an open reading frame of 754 residues. The deduced amino acid sequence showed 33.6% and 34.1% overall identity with the human Bf and C2 sequences, respectively, hence this clone was named medaka Bf/C2. The single-copy medaka Bf/C2 gene had exactly the same exon-intron organization as the mammalian Bf and C2 genes, and spanned about 8 kilobases. The Bf/C2 locus was mapped to the close proximity (2.9 cM) of the superoxide dismutase locus on the linkage group XX by the use of a restriction site polymorphism between two inbred strains of the medaka.
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