ArticleThe Journal of clinical investigation1996
Gene mapping of familial autosomal dominant dilated cardiomyopathy to chromosome 10q21-23.
Article in The Journal of clinical investigation, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 148 citations in OpenAlex.
- Intellectual disability: dendritic anomalies and emerging genetic perspectives.Acta neuropathologica · 2021Review
- Current Discoveries and Interventions for Barlow's Disease.Current cardiology reports · 2016Review
- Mendelian forms of structural cardiovascular disease.Current cardiology reports · 2013Review
- Monogenic atrial fibrillation as pathophysiological paradigms.Cardiovascular research · 2011Review
- A teenager with Marfan syndrome and left ventricular noncompaction.Pediatric cardiology · 2010Article
- [Genetics of atrial fibrillation: rare mutations, common variants and clinical relevance?].Herzschrittmachertherapie & Elektrophysiologie · 2006Review
- A novel locus for autosomal-dominant dilated cardiomyopathy maps to chromosome 7q22.3-31.1.Human genetics · 2005Article
- Molecular genetic analysis of six Dutch families with atrial fibrillation.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2005Article
- Congenital semilunar valvulogenesis defect in mice deficient in phospholipase C epsilon.Molecular and cellular biology · 2005Article
- Genetic Counseling and Screening Issues in Familial Dilated Cardiomyopathy.Journal of genetic counseling · 2001Article
- Many roads lead to a broken heart: the genetics of dilated cardiomyopathy.American journal of human genetics · 2001Review
- A new locus for autosomal dominant dilated cardiomyopathy identified on chromosome 6q12-q16.American journal of human genetics · 2001Article
- Haemochromatosis gene mutations in idiopathic dilated cardiomyopathy.Heart (British Cardiac Society) · 2000Article
- Dystrophin and the cardiomyocyte membrane cytoskeleton in the healthy and failing heart.Heart failure reviews · 2000Article
- Genetic abnormalities responsible for dilated cardiomyopathy.Current cardiology reports · 2000Review
- Mutations in the human delta-sarcoglycan gene in familial and sporadic dilated cardiomyopathy.The Journal of clinical investigation · 2000Article
- Review
- Mapping of a first locus for autosomal dominant myxomatous mitral-valve prolapse to chromosome 16p11.2-p12.1.American journal of human genetics · 1999Article
- Investigation of a family with autosomal dominant dilated cardiomyopathy defines a novel locus on chromosome 2q14-q22.American journal of human genetics · 1999Article
- The molecular genetics of arrhythmias and sudden death.Clinical cardiology · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dilated cardiomyopathy (DCM) is the most common form of primary myocardial disorder, accounting for 60% of all cardiomyopathies. In 20-30% of cases, familial inheritance can be demonstrated; an autosomal dominant transmission is the usual type of inheritance pattern identified. Previously, genetic heterogeneity was demonstrated in familial autosomal dominant dilated cardiomyopathy (FDCM). Gene localization to chromosome 1 (1p1-1q1 and 1q32), chromosome 3 (3p25-3p22), and chromosome 9 (9q13-9q22) has recently been identified. We report one family with 26 members (12 affected) with familial autosomal dominant dilated cardiomyopathy in which linkage to chromosome 10 at the 10q21-q23 locus is identified. Using short tandem repeat polymorphism (STR) markers with heterozygosity > 70%, 169 markers (50% of the genome) were used before linkage was found to markers D10S605 and D10S201 with a pairwise LOD score = 3.91, theta = 0, penetrance = 100% for both markers. Linkage to 1p1-1q1, 1q32, 3p25-3p22, and 9q13-9q22 was excluded. We conclude that a new locus for pure autosomal dominant FDCM exists, and that this gene is localized to a 9 cM region of 10q21-10q23. The search for the disease causing gene and the responsible mutation(s) is ongoing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.