ArticleThe Journal of physiology1996
Three distinct chloride channels control anion movements in rat parotid acinar cells.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 67 citations in OpenAlex.
- Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype.The Journal of physiology · 2023Article
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- Cell Death Induction and Protection by Activation of Ubiquitously Expressed Anion/Cation Channels. Part 1: Roles of VSOR/VRAC in Cell Volume Regulation, Release of Double-Edged Signals and Apoptotic/Necrotic Cell Death.Frontiers in cell and developmental biology · 2020Review
- Research and progress on ClC‑2 (Review).Molecular medicine reports · 2017Review
- A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Control of volume-sensitive chloride channel inactivation by the coupled action of intracellular chloride and extracellular protons.Pflugers Archiv : European journal of physiology · 2010Article
- Stimulation of mucosal secretion by lubiprostone (SPI-0211) in guinea pig small intestine and colon.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Clcn2 encodes the hyperpolarization-activated chloride channel in the ducts of mouse salivary glands.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- A synthetic prostone activates apical chloride channels in A6 epithelial cells.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
- A variant of the Ca2+-activated Cl channel Best3 is expressed in mouse exocrine glands.The Journal of membrane biology · 2008Article
- Molecular and functional analyses of two new calcium-activated chloride channel family members from mouse eye and intestine.The Journal of biological chemistry · 2004Article
- Permeant anions control gating of calcium-dependent chloride channels.The Journal of membrane biology · 2004Article
- Modulation of calcium-dependent chloride secretion by basolateral SK4-like channels in a human bronchial cell line.The Journal of membrane biology · 2003Article
- A novel chloride conductance activated by extracellular ATP in mouse parotid acinar cells.The Journal of physiology · 2003Article
- Conformation-dependent regulation of inward rectifier chloride channel gating by extracellular protons.The Journal of physiology · 2002Article
- Expression of volume-sensitive Cl(-) channels and ClC-3 in acinar cells isolated from the rat lacrimal gland and submandibular salivary gland.The Journal of physiology · 2001Article
- Osmosensitive C1- currents and their relevance to regulatory volume decrease in human intestinal T84 cells: outwardly vs. inwardly rectifying currents.The Journal of physiology · 1998Article
- Characterization of the hyperpolarization-activated chloride current in dissociated rat sympathetic neurons.The Journal of physiology · 1998Article
- Molecular dissection of gating in the ClC-2 chloride channel.The EMBO journal · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
1. We used the whole-cell configuration of the patch clamp technique to examine the different macroscopic Cl- currents present in single rat parotid acinar cells. 2. Cell swelling produced by negative osmotic pressure (hypotonic bath solutions) induced a large outwardly rectifying Cl- current with little or no time and voltage dependence. In contrast, an increase in intracellular [Ca2+] induced by ionomycin activated Cl- currents with very different properties. Ca(2+)-activated Cl- currents showed outward rectification, relatively slow activation kinetics and marked voltage dependence. These results are consistent with the existence of two different outwardly rectifying Cl- channels in rat parotid cells. 3. In conditions designed to eliminate the activation of these two Cl- currents, a third type of current was observed. This third current was activated in a time-dependent manner by hyperpolarized potentials and was about equally permeant to Cl-, I- and Br-. 4. The properties of the hyperpolarization-activated current were similar to those of the cloned ClC-2 channel. Polymerase chain reaction-based methods and ribonuclease protection analyses indicated the presence in parotid gland of mRNA homologous to ClC-2. 5. Individual parotid acinar cells expressed all three types of Cl- channels. Each type of channel may contribute to Cl- efflux in distinct stages of the secretion process depending on the intracellular [Ca2+], cell volume and membrane potential.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.