ArticleThe Journal of physiology1996
Control of action potential propagation by intracellular Ca2+ in cultured rat dorsal root ganglion cells.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Calcium and arrhythmogenesis.Physiological reviews · 2007Pooled it
- Neuronal Activity in the Sciatic Nerve Is Accompanied by Immediate Cytoskeletal Changes.Frontiers in molecular neuroscience · 2021Article
- Pathological pain processing in mouse models of multiple sclerosis and spinal cord injury: contribution of plasma membrane calcium ATPase 2 (PMCA2).Journal of neuroinflammation · 2019Article
- Autophosphorylated CaMKII Facilitates Spike Propagation in Rat Optic Nerve.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Imaging of electrical activity in small diameter fibers of the murine peripheral nerve with virally-delivered GCaMP6f.Scientific reports · 2018Article
- D3 Receptors Regulate Excitability in a Unique Class of Prefrontal Pyramidal Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- β-Arrestin-Dependent Dopaminergic Regulation of Calcium Channel Activity in the Axon Initial Segment.Cell reports · 2016Article
- N- and L-Type Voltage-Gated Calcium Channels Mediate Fast Calcium Transients in Axonal Shafts of Mouse Peripheral Nerve.Frontiers in cellular neuroscience · 2016Article
- Calcium-Activated Potassium Channels at Nodes of Ranvier Secure Axonal Spike Propagation.Cell reports · 2015Article
- Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C-type units after painful nerve injury.The Journal of physiology · 2013Article
- Ca²⁺-dependent regulation of Ca²⁺ currents in rat primary afferent neurons: role of CaMKII and the effect of injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Painful nerve injury increases plasma membrane Ca2+-ATPase activity in axotomized sensory neurons.Molecular pain · 2012Article
- Short- and long-term plasticity at the axon initial segment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Review
- Dopaminergic modulation of axon initial segment calcium channels regulates action potential initiation.Neuron · 2010Article
- Article
- Epac activation, altered calcium homeostasis and ventricular arrhythmogenesis in the murine heart.Pflugers Archiv : European journal of physiology · 2008Article
- Contribution of calcium channel subtypes to the intracellular calcium signal in sensory neurons: the effect of injury.Anesthesiology · 2007Article
- Role of decreased sensory neuron membrane calcium currents in the genesis of neuropathic pain.Croatian medical journal · 2007Review
- Painful peripheral nerve injury decreases calcium current in axotomized sensory neurons.Anesthesiology · 2006Article
- Characterization of action potential-evoked calcium transients in mouse postganglionic sympathetic axon bundles.The Journal of physiology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. To assess the role of intracellular Ca2+ in action potential (AP) propagation, whole-cell recordings of cultured dorsal root ganglion (DRG) cells were carried out while Ca2+ was simultaneously measured with a laser-scanning confocal microscope. 2. Flash photolytic liberation of a Ca2+ buffer during trains of APs which partly failed to invade the DRG cell body immediately lowered intracellular Ca2+ and restored safe AP propagation. Furthermore, the speed of the propagated AP was reduced considerably when intracellular Ca2+ was increased by flash photolysis of caged Ca2+. 3. Both results suggest that intracellular Ca2+ regulates the safety factor for AP propagation and may thus provide a control mechanism for synaptic integration, which acts pre- as well as postsynaptically.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.