ArticleThe Journal of physiology1996
Dissociation of subsarcolemmal from global cytosolic [Ca2+] in myocytes from guinea-pig coronary artery.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Potassium channels in vascular smooth muscle cells.Physiological reviews · 2026Review
- Altered calcium sensitivity contributes to enhanced contractility of collateral-dependent coronary arteries.Journal of applied physiology (Bethesda, Md. : 1985) · 2004Article
- Ca(2+) influx and opening of Ca(2+)-activated K(+) channels in muscle fibers from control and mdx mice.Biophysical journal · 2002Article
- Local Ca(2+) transients and distribution of BK channels and ryanodine receptors in smooth muscle cells of guinea-pig vas deferens and urinary bladder.The Journal of physiology · 2001Article
- Enhanced L-type Ca2+ channel current density in coronary smooth muscle of exercise-trained pigs is compensated to limit myoplasmic free Ca2+ accumulation.The Journal of physiology · 2000Article
- Two Ca2+ entry pathways mediate InsP3-sensitive store refilling in guinea-pig colonic smooth muscle.The Journal of physiology · 2000Article
- Elevated subsarcolemmal Ca2+ in mdx mouse skeletal muscle fibers detected with Ca2+-activated K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Pregnancy switches adrenergic signal transduction in rat and human uterine myocytes as probed by BKCa channel activity.The Journal of physiology · 2000Article
- Augmentation of SR Ca(2+) release by rapamycin and FK506 causes K(+)-channel activation and membrane hyperpolarization in bladder smooth muscle.British journal of pharmacology · 2000Article
- Sympathetic neuroeffector transmission in the rat anococcygeus muscle.The Journal of physiology · 1999Article
- Effects of peroxide on contractility of coronary artery rings of different sizes.Molecular and cellular biochemistry · 1999Article
- Ca2+ influx through carbachol-activated non-selective cation channels in guinea-pig gastric myocytes.The Journal of physiology · 1998Article
- In situ characterization of the Ca2+ sensitivity of large conductance Ca2+-activated K+ channels: implications for their use as near-membrane Ca2+ indicators in smooth muscle cells.Biophysical journal · 1998Article
- Ca2+ images and K+ current during depolarization in smooth muscle cells of the guinea-pig vas deferens and urinary bladder.The Journal of physiology · 1998Article
- Modulation of Ca(2+)-activated Cl- currents in rabbit portal vein smooth muscle by an inhibitor of mitochondrial Ca2+ uptake.The Journal of physiology · 1997Article
- Elementary and global aspects of calcium signalling.The Journal of physiology · 1997Review
- The temporal profile of calcium transients in voltage clamped gastric myocytes from Bufo marinus.The Journal of physiology · 1996Article
- Analysis of the time course of calcium-activated chloride "tail" currents in rabbit portal vein smooth muscle cells.Pflugers Archiv : European journal of physiology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Changes in cytosolic Ca2+ concentration (delta[Ca2+]c) were measured by global indo-1 fluorescence and compared with changes in subsarcolemmal Ca2+ concentration (delta[Ca2+]sl) indicated by Ca(2+)-activated K+ currents (IK(Ca)). 2. At -50 mV holding potential, 10mM caffeine increased both IK(Ca) and [Ca2+]c without measurable delay. While IK(Ca) peaked within 0.3 +/- 0.16 s (mean +/- S.D.) and decayed to 50% within 0.4 +/- 0.2 s, delta[Ca2+]c peaked within 1.5 +/- 0.5 s and decayed to 50% within 5.2 +/- 1.0 s. The different time courses support the idea that [Ca2+]sl and [Ca2+]c deviate. 3. When 10 mM caffeine was applied 20 s after an initial 2 s caffeine application, IK(Ca) was suppressed to 22 +/- 5% and delta [Ca2+]c to 40 +/- 4%. During the following 1 min caffeine-free period, IK(Ca) recovered to 61 +/- 7% while delta [Ca2+]c remained at 40 +/- 3%. The differences between IK(Ca) and delta[Ca2+]c suggest that Ca2+ deprivation and Ca2+ refilling is faster in peripheral than in central sarcoplasmic reticulum (SR). 4. During the loading period of indo-1, a spontaneous delta[Ca2+]c of 30-80 nM appeared both at -50 mV and at more positive potentials. The amplitude of spontaneous delta[Ca2+]c increased with the amplitude, the frequency or the fusion of spontaneous transient outward currents (STOCs). 5. Block of sarcolemmal Ca2+ fluxes by 1 mM La3+ increased [Ca2+]c by 250 +/- 100 nM and suppressed the spontaneous delta[Ca2+]c. However, La3+ did not significantly retard the rate of decay of STOCs which may therefore be limited by Ca2+ diffusion into the cytosol and not by Ca2+ extrusion. 6. The dissociation of IK(Ca) (or STOCs) and delta[Ca2+]c may indicate a Ca2+ concentration gradient during Ca2+ release directed from the sarcolemma towards the centre of the cell, which later reverses direction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.