ReviewCancer metastasis reviews1995
The role of fibroblasts in tumor behavior.
Review in Cancer metastasis reviews, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 123 citations in OpenAlex.
- Dimerization of EGFR and HER2 induces breast cancer cell motility through STAT1-dependent ACTA2 induction.Oncotarget · 2017Article
- Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer.Nature communications · 2017Article
- Changes in the gene expression of co-cultured human fibroblast cells and osteosarcoma cells: the role of microenvironment.Oncotarget · 2015Article
- Improving prediction of prostate cancer recurrence using chemical imaging.Scientific reports · 2015Article
- Simulating tumor microenvironment: changes in protein expression in an in vitro co-culture system.Cancer cell international · 2014Article
- Podoplanin, α-smooth muscle actin or S100A4 expressing cancer-associated fibroblasts are associated with different prognosis in colorectal cancers.Journal of Korean medical science · 2013Article
- Myofibroblast activation in colorectal cancer lymph node metastases.British journal of cancer · 2013Article
- Determining prostate cancer-specific death through quantification of stromogenic carcinoma area in prostatectomy specimens.The American journal of pathology · 2011Article
- Stochastic modelling of biased cell migration and collagen matrix modification.Journal of mathematical biology · 2010Article
- Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions.Cell communication and signaling : CCS · 2010Article
- YKL-40-A Protein in the Field of Translational Medicine: A Role as a Biomarker in Cancer Patients?Cancers · 2010Article
- Hedgehog signalling in breast cancer.Carcinogenesis · 2009Review
- Article
- Role of genetic polymorphisms in tumour angiogenesis.British journal of cancer · 2002Review
- Inhibition of endothelial cell functions and of angiogenesis by the metastasis inhibitor NAMI-A.British journal of cancer · 2002Article
- Differential expression of protease-activated receptors-1 and -2 in stromal fibroblasts of normal, benign, and malignant human tissues.The American journal of pathology · 2001Article
- c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma.The American journal of pathology · 2001Article
- In vivo and in vitro interactions between human colon carcinoma cells and hepatic stellate cells.Japanese journal of cancer research : Gann · 2000Article
- Cloning of an isoform of integrin-linked kinase (ILK) that is upregulated in HT-144 melanoma cells following TGF-beta1 stimulation.Oncogene · 2000Article
- Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.Genes & development · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prominent desmoplastic or stromal reaction seen in many invasive carcinomas suggests that stromal cells play a role in cancer pathogenesis. Investigations based on cell typing, using antibodies to cytoskeletal constituents, have revealed that most tumors contain various types of fibroblasts. Stromal cells with myofibroblastic differentiation features are the predominant cell type at the periphery of epithelial tumors. These tumor-activated fibroblasts play a major role in tumor development and spread, affecting the proliferation, differentiation, invasion or regression of cancer cells. This review considers the events inducing the different fibroblastic responses and the role of tumor-activated fibroblasts in both tumor development and anti-cancer treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.