ArticleThe Histochemical journal1996
Changes in the distribution of fibrillar collagens in the collateral and cruciate ligaments of the rabbit knee joint during fetal and postnatal development.
Article in The Histochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 23 citations in OpenAlex.
- Embryonic and fetal development of the human knee with an emphasis on the posterior cruciate ligament: a literature review.Annals of joint · 2025Review
- Article
- Collagen fibre and fibril ultrastructural arrangement of the superficial medial collateral ligament in the human knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
- Collagen fibre arrangement and functional crimping pattern of the medial collateral ligament in the rat knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2010Article
- Proteoglycans and catabolic products of proteoglycans present in ligament.The Biochemical journal · 2005Article
- The hip joint: the fibrillar collagens associated with development and ageing in the rabbit.Journal of anatomy · 2001Article
- Fetal and postnatal development of the patella, patellar tendon and suprapatella in the rabbit; changes in the distribution of the fibrillar collagens.Journal of anatomy · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The collateral ligaments can be clearly distinguished in the 25-day fetal rabbit knee joint. Type I and V collagens are present in the extracellular matrix between the cells of the lateral and medial collateral ligaments and this distribution persists until the rabbit is skeletally mature. From 8 months onwards type III collagen is also present, particularly around the cells. Type I collagen mRNA is expressed by the cells from the 25-day fetal to 8-month-old adult ligament. The ligament sheath is composed of types III and V collagens. The cruciate ligaments are present between the femur and tibia in the 20-day fetus. The matrix is composed of types I and V collagens from the 25-day fetus until at 12- to 14-weeks postnatal, type III collagen appears in the pericellular regions together with type V. At 8 months and 2 years the amount of type III collagen has increased. All the cells express the mRNA for type I collagen at 12- to 14-weeks, but only isolated cells express this mRNA at 8 months. Thus, both the collateral and cruciate ligaments undergo changes in their complement of collagens during postnatal development and ageing. The implications of these complex interactions of different types of collagen are discussed in relation to healing and the surgical replacement of torn ligaments by tendons.
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