ReviewMolecular neurobiology1996
A composite model for establishing the microtubule arrays of the neuron.
Review in Molecular neurobiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed.
- Neuronal Calcium Signaling and Cytoskeletal Dynamics in Neurodegeneration.International journal of molecular sciences · 2026Review
- Polarity reversal of stable microtubules during neuronal development.Journal of cell science · 2025Article
- Regulation of Axonal Microtubule Polarity Orientation in Different Kinds of Neurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Phase separation of microtubule-binding proteins - implications for neuronal function and disease.Journal of cell science · 2024Review
- Dynein-mediated microtubule translocation powering neurite outgrowth in chick andJournal of cell science · 2020Article
- Article
- Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity.Nature communications · 2016Article
- Sweet taste receptor signaling network: possible implication for cognitive functioning.Neurology research international · 2015Review
- Γ-tubulin controls neuronal microtubule polarity independently of Golgi outposts.Molecular biology of the cell · 2014Article
- Spastin-interacting protein NA14/SSNA1 functions in cytokinesis and axon development.PloS one · 2014Article
- Spatial and temporal sensing limits of microtubule polarization in neuronal growth cones by intracellular gradients and forces.Biophysical journal · 2012Article
- Hooks and comets: The story of microtubule polarity orientation in the neuron.Developmental neurobiology · 2011Review
- Centrosome motility is essential for initial axon formation in the neocortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Drosophila brain development: closing the gap between a macroarchitectural and microarchitectural approach.Cold Spring Harbor symposia on quantitative biology · 2009Article
- Models of motor-assisted transport of intracellular particles.Biophysical journal · 2001Article
- Depletion of a microtubule-associated motor protein induces the loss of dendritic identity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Axonal transport of microtubule-associated protein 1B (MAP1B) in the sciatic nerve of adult rat: distinct transport rates of different isoforms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- An essential role for katanin in severing microtubules in the neuron.The Journal of cell biology · 1999Article
- Visualization of melanosome dynamics within wild-type and dilute melanocytes suggests a paradigm for myosin V function In vivo.The Journal of cell biology · 1998Article
- Katanin is responsible for the M-phase microtubule-severing activity in Xenopus eggs.Molecular biology of the cell · 1998Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurons generate two distinct types of processes, termed axons and dendrites, both of which rely on a highly organized array of microtubules for their growth and maintenance. Axonal microtubules are uniformly oriented with their plus ends distal to the cell body, whereas dendritic microtubules are nonuniformly oriented. In neither case are the microtubules attached to the centrosome or any detectable structure that could establish their distinct patterns of polarity orientation. Studies from our laboratory over the past few years have led us to propose the following model for the establishment of the axonal and dendritic microtubule arrays. Microtubules destined for these processes are nucleated at the centrosome within the cell body of the neuron and rapidly released. The released microtubules are then transported into developing axons and dendrites to support their growth. Early in neuronal development, the microtubules are transported with their plus ends leading into immature processes that are the common progenitors of both axons and dendrites. This sets up a uniformly plus-end distal pattern of polarity orientation, which is preserved in the developing axon. In the case of the dendrite, the plus-end-distal microtubules are joined by another population of microtubules that are transported into these processes with their minus-ends leading. Implicit in this model is that neurons have specialized machinery for regulating the release of microtubules from the centrosome and for transporting them with great specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.