ReviewMolecular neurobiology1996
Role of laminin and integrin interactions in growth cone guidance.
Review in Molecular neurobiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 101 citations in OpenAlex.
- High throughput 3D gel-based neural organotypic model for cellular assays using fluorescence biosensors.Communications biology · 2022Article
- Tau Protein Interaction Partners and Their Roles in Alzheimer's Disease and Other Tauopathies.International journal of molecular sciences · 2021Review
- Tunable methacrylated hyaluronic acid-based hydrogels as scaffolds for soft tissue engineering applications.Journal of biomedical materials research. Part A · 2020Article
- The schizophrenia risk gene MIR137 acts as a hippocampal gene network node orchestrating the expression of genes relevant to nervous system development and function.Progress in neuro-psychopharmacology & biological psychiatry · 2017Article
- Nongenomic actions of thyroid hormone.Nature reviews. Endocrinology · 2016Review
- Comparison of sensory neuron growth cone and filopodial responses to structurally diverse aggrecan variants, in vitro.Experimental neurology · 2013Article
- Activation of ezrin/radixin/moesin mediates attractive growth cone guidance through regulation of growth cone actin and adhesion receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Article
- Cellular strategies of axonal pathfinding.Cold Spring Harbor perspectives in biology · 2010Review
- Suspension matrices for improved Schwann-cell survival after implantation into the injured rat spinal cord.Journal of neurotrauma · 2010Article
- A novel biological function for CD44 in axon growth of retinal ganglion cells identified by a bioinformatics approach.Journal of neurochemistry · 2007Article
- Axon extension in the fast and slow lanes: substratum-dependent engagement of myosin II functions.Developmental neurobiology · 2007Article
- Myristoylated, alanine-rich C-kinase substrate phosphorylation regulates growth cone adhesion and pathfinding.Molecular biology of the cell · 2006Article
- Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Integrins regulate responsiveness to slit repellent signals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Rapid neuromodulatory actions of integrin ligands.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Plasma membrane ganglioside sialidase regulates axonal growth and regeneration in hippocampal neurons in culture.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Use of genetically modified glial cells overexpressing laminin alpha1-chain peptides in neurite outgrowth studies.Cellular and molecular neurobiology · 2000Article
- Local presentation of substrate molecules directs axon specification by cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Bradykinin-induced collapse of rat pheochromocytoma (PC12) cell growth cones: a role for tyrosine kinase activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laminin is well known to promote neuronal adhesion and axonal growth, but recent experiments suggest laminin has a wider role in guiding axons, both in development and regeneration. In vitro experiments demonstrate that laminin can alter the rate and direction of axonal growth, even when growth cone contact with laminin is transient. Investigations focused on a single neuronal type, such as retinal ganglion cells (RGCs), strongly implicate laminin as an important guidance molecule in development and suggest the involvement of integrins. Integrins are receptors for laminin, and neurons express multiple types of integrins that bind laminin. Morphologically, integrins cluster in point contacts, specialized regions of the growth cone that may coordinately regulate adhesion and motility. Recent evidence suggests that the structure and regulation of point contacts may differ from that of their nonneuronal counterpart, focal contacts. In part, this may be because the interaction of the cytoplasmic domain of integrin with the cytoskeleton is different in point contacts and focal contracts. Mutational studies where the cytoplasmic domain is truncated or altered are leading to a better understanding of the role of the alpha and beta subunit in regulating integrin clustering and binding to the cytoskeleton. In addition, whereas integrins may regulate motility through direct physical linkages to the growth cone cytoskeleton, an equally important role is their ability to elicit signaling, both through protein tyrosine phosphorylation and modulating calcium levels. Through such mechanisms integrins likely regulate the dynamic attachment and detachment of the growth cone as it moves on laminin substrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.