ReviewJournal of neuro-oncology1996
Growth factor receptors and medulloblastoma.
Review in Journal of neuro-oncology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 17 citations in OpenAlex.
- Angiogenesis and angiogenic tyrosine kinase receptor expression in pediatric brain tumors.Pathology oncology research : POR · 2014Article
- Tissue factor mediates the HGF/Met-induced anti-apoptotic pathway in DAOY medulloblastoma cells.Journal of neuro-oncology · 2010Article
- Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators.Clinical cancer research : an official journal of the American Association for Cancer Research · 2008Article
- Roles of transforming growth factor-alpha and related molecules in the nervous system.Molecular neurobiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth factors and their receptors play important roles in the regulation of cell division, development and differentiation. Neurotrophins are growth factors which have not been shown, until recently, to be associated with human neoplasia. Medulloblastoma is a central nervous system tumor which is thought to arise from the external granule cell layer of the cerebellum. Platelet Derived Growth Factor (PDGF) or Epidermal Growth Factor (EGF) and/or their receptors have not been found to have a significant role in the development of this tumor. Neurotrophins, however, which regulate cerebellar development in a time-dependent manner, appear to be important in medulloblastoma and the presence of high levels of TrkC expression, a neurotrophin receptor, is associated with a better outcome. The potential role of these growth factors and their receptors in manipulating the behavior of this tumor is discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.