ArticleProceedings of the National Academy of Sciences of the United States of America1996
Long-term potentiation increases tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit 2B in rat dentate gyrus in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 175 citations in OpenAlex.
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- Girdin phosphorylation is crucial for synaptic plasticity and memory: a potential role in the interaction of BDNF/TrkB/Akt signaling with NMDA receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia.Frontiers in cellular neuroscience · 2013Article
- β-Estradiol unmasks metabotropic receptor-mediated metaplasticity of NMDA receptor transmission in the female rat dentate gyrus.Psychoneuroendocrinology · 2012Article
- Tinnitus: pathology of synaptic plasticity at the cellular and system levels.Frontiers in systems neuroscience · 2012Article
- Effects of Electroacupuncture on N-Methyl-D-aspartate Receptor-Related Signaling Pathway in the Spinal Cord of Normal Rats.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Regulation of long-term plasticity induction by the channel and C-terminal domains of GluN2 subunits.Molecular neurobiology · 2011Review
- Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors.Nature medicine · 2011Article
- Molecular mechanisms underlying memory consolidation of taste information in the cortex.Frontiers in behavioral neuroscience · 2011Article
- Tyrosine phosphorylation of the N-Methyl-D-Aspartate receptor 2B subunit in spinal cord contributes to remifentanil-induced postoperative hyperalgesia: the preventive effect of ketamine.Molecular pain · 2009Article
- Tyrosine phosphorylation of the 2B subunit of the NMDA receptor is necessary for taste memory formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia.Neuroscience · 2008Article
- Inhibition of NR2B phosphorylation restores alterations in NMDA receptor expression and improves functional recovery following traumatic brain injury in mice.Journal of neurotrauma · 2008Article
- Facilitation of taste memory acquisition by experiencing previous novel taste is protein-synthesis dependent.Learning & memory (Cold Spring Harbor, N.Y.) · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term potentiation (LTP) is a form of synaptic memory that may subserve developmental and behavioral plasticity. An intensively investigated form of LTP is dependent upon N-methyl-D-aspartate (NMDA) receptors and can be elicited in the dentate gyrus and hippocampal CA1. Induction of this type of LTP is triggered by influx of Ca2+ through activated NMDA receptors, but the downstream mechanisms of induction, and even more so of LTP maintenance, remain controversial. It has been reported that the function of NMDA receptor channel can be regulated by protein tyrosine kinases and protein phosphatases and that inhibition of protein tyrosine kinases impairs induction of LTP. Herein we report that LTP in the dentate gyrus is specifically correlated with tyrosine phosphorylation of the NMDA receptor subunit 2B in an NMDA receptor-dependent manner. The effect is observed with a delay of several minutes after LTP induction and persists in vivo for several hours. The potential relevance of this post-translational modification to mechanisms of LTP and circuit plasticity is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.