ArticleProceedings of the National Academy of Sciences of the United States of America1996
Interleukin 7 independent development of human B cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 142 citations in OpenAlex.
- Hematopoietic stem cell gene editing rescues B-cell development in X-linked agammaglobulinemia.The Journal of allergy and clinical immunology · 2024Article
- CRISPR/Cas9-Based Disease Modeling and Functional Correction of Interleukin 7 Receptor Alpha Severe Combined Immunodeficiency in T-Lymphocytes and Hematopoietic Stem Cells.Human gene therapy · 2024Article
- Article
- Review
- An instructive role for Interleukin-7 receptor α in the development of human B-cell precursor leukemia.Nature communications · 2022Article
- Ikaros-Associated Diseases: From Mice to Humans and Back Again.Frontiers in pediatrics · 2021Review
- Regulation of Energy Metabolism during Early B Lymphocyte Development.International journal of molecular sciences · 2018Review
- Molecular Regulation of Differentiation in Early B-Lymphocyte Development.International journal of molecular sciences · 2018Review
- Effects of autologous stromal cells and cytokines on differentiation of equine bone marrow-derived progenitor cells.American journal of veterinary research · 2017Article
- Early B lymphocyte development: Similarities and differences in human and mouse.World journal of stem cells · 2014Review
- Crucial roles of interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity.Journal of virology · 2014Article
- B cell biology: an overview.Current allergy and asthma reports · 2014Review
- Interleukin 7 and thymic stromal lymphopoietin: from immunity to leukemia.Cellular and molecular life sciences : CMLS · 2014Review
- IL-7R expression and IL-7 signaling confer a distinct phenotype on developing human B-lineage cells.Blood · 2011Article
- Review
- Prospective isolation of clonogenic mantle cell lymphoma-initiating cells.Stem cell research · 2010Article
- The density of CD10 corresponds to commitment and progression in the human B lymphoid lineage.PloS one · 2010Article
- Stromal cell-free conditions favorable for human B lymphopoiesis in culture.Journal of immunological methods · 2010Article
- IL-7 Dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- A conserved gene family encodes transmembrane proteins with fibronectin, immunoglobulin and leucine-rich repeat domains (FIGLER).BMC biology · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mammalian hematopoietic stem cell (HSC) commitment and differentiation into lymphoid lineage cells proceed through a series of developmentally restricted progenitor compartments. A complete understanding of this process, and how it differs from HSC commitment and differentiation into cells of the myeloid/erythroid lineages, requires the development of model systems that support HSC commitment to the lymphoid lineages. We now describe a human bone marrow stromal cell culture that preferentially supports commitment and differentiation of human HSC to CD19+ B-lineage cells. Fluorescence activated cell sorterpurified CD34++/lineage-cells were isolated from fetal bone marrow and cultured on human fetal bone marrow stromal cells in serum-free conditions containing no exogenous cytokines. Over a period of 3 weeks, CD34++/lineage- cells underwent commitment, differentiation, and expansion into the B lineage. Progressive changes included: loss of CD34, acquisition of and graded increases in the level of cell surface CD19, and appearance of immature B cells expressing mu/kappa or mu/lambda cell surface Ig receptors. The tempo and phenotype of B-cell development was not influenced by the addition of IL-7 (10 ng/ml), or by the addition of goat anti-IL-7 neutralizing antibody. These results indicate a profound difference between mouse and human in the requirement for IL-7 in normal B-cell development, and provide an experimental system to identify and characterize human bone marrow stromal cell-derived molecules crucial for human B lymphopoiesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.