ArticleProceedings of the National Academy of Sciences of the United States of America1996
Ethanol causes translocation of cAMP-dependent protein kinase catalytic subunit to the nucleus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 113 citations in OpenAlex.
- Review
- Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation.Cell communication and signaling : CCS · 2020Article
- Differential expression of long-term potentiation among identified inhibitory inputs to dopamine neurons.Journal of neurophysiology · 2017Article
- TLR4 signaling in VTA dopaminergic neurons regulates impulsivity through tyrosine hydroxylase modulation.Translational psychiatry · 2016Article
- Regulation of Extrasynaptic GABAA α4 Receptors by Ethanol-Induced Protein Kinase A, but Not Protein Kinase C Activation in Cultured Rat Cerebral Cortical Neurons.The Journal of pharmacology and experimental therapeutics · 2016Article
- Phosphodiesterase regulation of alcohol drinking in rodents.Alcohol (Fayetteville, N.Y.) · 2015Review
- Moderate alcohol induces stress proteins HSF1 and hsp70 and inhibits proinflammatory cytokines resulting in endotoxin tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Ethanol activation of protein kinase A regulates GABAA α1 receptor function and trafficking in cultured cerebral cortical neurons.The Journal of pharmacology and experimental therapeutics · 2013Article
- Changes in CREB activation in the prefrontal cortex and hippocampus blunt ethanol-induced behavioral sensitization in adolescent mice.Frontiers in integrative neuroscience · 2013Article
- Ethanol disrupts axon outgrowth stimulated by netrin-1, GDNF, and L1 by blocking their convergent activation of Src family kinase signaling.Journal of neurochemistry · 2012Article
- Ethanol Activation of Protein Kinase A Regulates GABA(A) Receptor Subunit Expression in the Cerebral Cortex and Contributes to Ethanol-Induced Hypnosis.Frontiers in neuroscience · 2012Article
- Neuroscience of alcoholism: molecular and cellular mechanisms.Cellular and molecular life sciences : CMLS · 2010Review
- Up-regulation of AGS3 during morphine withdrawal promotes cAMP superactivation via adenylyl cyclase 5 and 7 in rat nucleus accumbens/striatal neurons.Molecular pharmacology · 2009Article
- Protein kinases and addiction.Annals of the New York Academy of Sciences · 2008Review
- Dopamine and ethanol cause translocation of epsilonPKC associated with epsilonRACK: cross-talk between cAMP-dependent protein kinase A and protein kinase C signaling pathways.Molecular pharmacology · 2008Article
- Increased consumption but not operant self-administration of ethanol in mice lacking the RIIbeta subunit of protein kinase A.Alcoholism, clinical and experimental research · 2006Article
- Predictors of high ethanol consumption in RIIbeta knock-out mice: assessment of anxiety and ethanol-induced sedation.Alcoholism, clinical and experimental research · 2004Article
- Prolonged ethanol ingestion increases renal AQP2 and AQP3 expression in adult rats and in their offspring.The Journal of membrane biology · 2004Article
- Chronic ethanol exposure increases the binding of HuR to the TNFalpha 3'-untranslated region in macrophages.The Journal of biological chemistry · 2003Article
- The role of GABAA receptors in mediating the effects of alcohol in the central nervous system.Journal of psychiatry & neuroscience : JPN · 2003Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Short- and long-term ethanol exposures have been shown to alter cellular levels of cAMP, but little is known about the effects of ethanol on cAMP-dependent protein kinase (PKA). When cAMP levels increase, the catalytic subunit of PKA (C alpha) is released from the regulatory subunit, phosphorylates nearby proteins, and then translocates to the nucleus, where it regulates gene expression. Altered localization of C alpha would have profound effects on multiple cellular functions. Therefore, we investigated whether ethanol alters intracellular localization of C alpha. NG108-15 cells were incubated in the presence or absence of ethanol for as long as 48 h, and localization of PKA subunits was determined by immunocytochemistry. We found that ethanol exposure produced a significant translocation of C alpha from the Golgi area to the nucleus. C alpha remained in the nucleus as long as ethanol was present. There was no effect of ethanol on localization of the type I regulatory subunit of PKA. Ethanol also caused a 43% decrease in the amount of type I regulatory subunit but had no effect on the amount of C alpha as determined by Western blot. These data suggest that ethanol-induced translocation of C alpha to the nucleus may account, in part, for diverse changes in cellular function and gene expression produced by alcohol.
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