ArticleProceedings of the National Academy of Sciences of the United States of America1996
Phosducin is a ubiquitous G-protein regulator.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 74 citations in OpenAlex.
- Phosducin-like 3 is a novel prognostic and onco-immunological biomarker in glioma: A multi-omics analysis with experimental verification.Frontiers in immunology · 2023Article
- Expression Profile of Housekeeping Genes and Tissue-Specific Genes in Multiple Tissues of Pigs.Animals : an open access journal from MDPI · 2022Article
- Structural Basis for the 14-3-3 Protein-Dependent Inhibition of Phosducin Function.Biophysical journal · 2017Article
- Experimental autoimmune uveitis and other animal models of uveitis: An update.Indian journal of ophthalmology · 2015Review
- CK2 phosphorylation of human centrins 1 and 2 regulates their binding to the DNA repair protein XPC, the centrosomal protein Sfi1 and the phototransduction protein transducin β.FEBS open bio · 2014Article
- Proliferative vitreoretinopathy may be a risk factor in combined macular hole retinal detachment cases.Retina (Philadelphia, Pa.) · 2013Article
- Phosphorylation of phosducin accelerates rod recovery from transducin translocation.Investigative ophthalmology & visual science · 2012Article
- The physiological roles of phosducin: from retinal function to stress-dependent hypertension.Cellular and molecular life sciences : CMLS · 2011Review
- Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction.Nature reviews. Neuroscience · 2007Review
- Phosducin-like proteins in Dictyostelium discoideum: implications for the phosducin family of proteins.The EMBO journal · 2003Article
- Endogenous mono-ADP-ribosylation of the free Gbetagamma prevents stimulation of phosphoinositide 3-kinase-gamma and phospholipase C-beta2 and is activated by G-protein-coupled receptors.The Biochemical journal · 2002Article
- Rethinking the role of phosducin: light-regulated binding of phosducin to 14-3-3 in rod inner segments.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Modulation of CRX transactivation activity by phosducin isoforms.Molecular and cellular biology · 2000Article
- Identification of bdm-1, a gene involved in G protein beta-subunit function and alpha-subunit accumulation.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- A small region in phosducin inhibits G-protein betagamma-subunit function.The EMBO journal · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosducin is a 33-kDa cytosolic regulator of G-protein-mediated signaling that has previously been thought to be specific for retina and pineal gland. In this study, we show widespread tissue distribution of phosducin by the amplification of its cDNA and the detection of two different transcripts in Northern analyses in liver, lung, heart, brain, and retina. On the protein level, phosducin could be detected in 12 bovine tissues by immune precipitation and subsequent Western analysis using anti-phosducin antibodies generated in two different species. Masking of phosducin in direct Western blots appears to explain the failure to detect phosducin in earlier studies. The concentration of phosducin in bovine brain was calculated in the range of 10 pmol/mg total cytosolic protein (approximately 1 microM), whereas in the other tissues, it was slightly less. In these concentrations, phosducin inhibited receptor-stimulated adenylyl cyclase activity in cell membranes by about 50%. Taken together, our results indicate that phosducin is a ubiquitous regulator of G-protein function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.