ArticleMolecular and cellular biology1996
NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 158 citations in OpenAlex.
- Unraveling the Role of NeuroD2 in Ischemic Pathophysiology: Insight into Neuroprotection Mechanisms Associated with AKT Survival Kinase.Neuromolecular medicine · 2025Article
- Article
- Disruption of NEUROD2 causes a neurodevelopmental syndrome with autistic features via cell-autonomous defects in forebrain glutamatergic neurons.Molecular psychiatry · 2021Article
- Terminal Differentiation of Adult Hippocampal Progenitor Cells Is a Step Functionally Dissociable from Proliferation and Is Controlled by Tis21, Id3 and NeuroD2.Frontiers in cellular neuroscience · 2017Article
- The transcription factor NeuroD2 coordinates synaptic innervation and cell intrinsic properties to control excitability of cortical pyramidal neurons.The Journal of physiology · 2016Article
- The Role of Atonal Factors in Mechanosensory Cell Specification and Function.Molecular neurobiology · 2015Article
- Genome-wide target analysis of NEUROD2 provides new insights into regulation of cortical projection neuron migration and differentiation.BMC genomics · 2015Article
- T-cell TGF-β signaling abrogation restricts medulloblastoma progression.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Skeletal muscle programming and re-programming.Current opinion in genetics & development · 2013Review
- NeuroD modulates opioid agonist-selective regulation of adult neurogenesis and contextual memory extinction.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Article
- Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis.The Journal of biological chemistry · 2012Article
- NeuroD2 regulates the development of hippocampal mossy fiber synapses.Neural development · 2012Article
- Article
- Transcriptional inhibition of REST by NeuroD2 during neuronal differentiation.Molecular and cellular neurosciences · 2010Article
- Transcriptional regulatory regions of gap43 needed in developing and regenerating retinal ganglion cells.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Cdc42-mTOR signaling pathway controls Hes5 and Pax6 expression in retinoic acid-dependent neural differentiation.The Journal of biological chemistry · 2009Article
- Article
- Basic helix-loop-helix transcription factor NEUROG1 and schizophrenia: effects on illness susceptibility, MRI brain morphometry and cognitive abilities.Schizophrenia research · 2008Article
- Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Cux2 (Cutl2) integrates neural progenitor development with cell-cycle progression during spinal cord neurogenesis.Development (Cambridge, England) · 2008Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have identified two new genes, neuroD2 and neuroD3, on the basis of their similarity to the neurogenic basic-helix-loop-helix (bHLH) gene neuroD. The predicted amino acid sequence of neuroD2 shows a high degree of homology to neuroD and MATH-2/NEX-1 in the bHLH region, whereas neuroD3 is a more distantly related family member. neuroD3 is expressed transiently during embryonic development, with the highest levels of expression between days 10 and 12. neuroD2 is initially expressed at embryonic day 11, with persistent expression in the adult nervous system. In situ and Northern (RNA) analyses demonstrate that different regions of the adult nervous system have different relative amounts of neuroD and neuroD2 RNA. Similar to neuroD, expression of neuroD2 in developing Xenopus laevis embryos results in ectopic neurogenesis, indicating that neuroD2 mediates neuronal differentiation. Transfection of vectors expressing neuroD and neuroD2 into P19 cells shows that both can activate expression through simple E-box-driven reporter constructs and can activate a reporter driven by the neuroD2 promoter region, but the GAP-43 promoter is preferentially activated by neuroD2. The noncongruent expression pattern and target gene specificity of these highly related neurogenic bHLH proteins make them candidates for conferring specific aspects of the neuronal phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.