ArticleMolecular and cellular biology1996
Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 31 citations in OpenAlex.
- Requirements for E1A dependent transcription in the yeast Saccharomyces cerevisiae.BMC molecular biology · 2009Article
- Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A.Journal of virology · 2004Article
- Adenovirus E1A requires the yeast SAGA histone acetyltransferase complex and associates with SAGA components Gcn5 and Tra1.Oncogene · 2002Article
- A role for coactivators and histone acetylation in estrogen receptor alpha-mediated transcription initiation.The EMBO journal · 2001Article
- Disruption of Ini1 leads to peri-implantation lethality and tumorigenesis in mice.Molecular and cellular biology · 2001Article
- Interaction of the E1A oncoprotein with Yak1p, a novel regulator of yeast pseudohyphal differentiation, and related mammalian kinases.Molecular biology of the cell · 2001Article
- P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL.The EMBO journal · 2000Article
- Mammalian SWI-SNF complexes contribute to activation of the hsp70 gene.Molecular and cellular biology · 2000Article
- Human SWI-SNF component BRG1 represses transcription of the c-fos gene.Molecular and cellular biology · 1999Article
- Direct interaction between Rsc6 and Rsc8/Swh3,two proteins that are conserved in SWI/SNF-related complexes.Nucleic acids research · 1998Article
- Role for ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression.Molecular and cellular biology · 1997Article
- Interaction of a Swi3 homolog with Sth1 provides evidence for a Swi/Snf-related complex with an essential function in Saccharomyces cerevisiae.Molecular and cellular biology · 1997Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Expression of the adenovirus E1A243 oncoprotein in Saccharomyces cerevisiae produces a slow-growth phenotype with accumulation of cells in the G1 phase of the cell cycle. This effect is due to the N-terminal and CR1 domains of E1A243, which in rodent cells are involved in triggering cellular transformation and also in binding to the cellular transcriptional coactivator p300. A genetic screen was undertaken to identify genes required for the function of E1A243 in S. cerevisiae. This screen identified SNF12, a gene encoding the 73-kDa subunit of the SWI/SNF transcriptional regulatory complex. Mutation of genes encoding known members of the SWI/SNF complex also led to loss of E1A function, suggesting that the SWI/SNF complex is a target of E1A243. Moreover, expression of E1A in wild-type cells specifically blocked transcriptional activation of the INO1 and SUC2 genes, whose activation pathways are distinct but have a common requirement for the SWI/SNF complex. These data demonstrate a specific functional interaction between E1A and the SWI/SNF complex and suggest that a similar interaction takes place in rodent and human cells.
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Registered trials
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