ArticleMolecular and cellular biology1996
Prenylated isoforms of yeast casein kinase I, including the novel Yck3p, suppress the gcs1 blockage of cell proliferation from stationary phase.
Article in Molecular and cellular biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 87 citations in OpenAlex.
- Phosphorylation-mediated regulation of the Nem1-Spo7/Pah1 phosphatase cascade in yeast lipid synthesis.Advances in biological regulation · 2022Review
- Mitochondrial Biogenesis Is Positively Regulated by Casein Kinase I Hrr25 Through Phosphorylation of Puf3 inGenetics · 2020Article
- Review
- Yck1 casein kinase I regulates the activity and phosphorylation of Pah1 phosphatidate phosphatase fromThe Journal of biological chemistry · 2019Article
- Aflatoxin levels in maize and peanut and blood in women and children: The case of Timor-Leste.Scientific reports · 2019Article
- Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator.The EMBO journal · 2016Article
- Phosphorylation of Elp1 by Hrr25 is required for elongator-dependent tRNA modification in yeast.PLoS genetics · 2015Article
- Microtubules depolymerization caused by the CK1 inhibitor IC261 may be not mediated by CK1 blockage.PloS one · 2014Article
- Saccharomyces cerevisiae Env7 is a novel serine/threonine kinase 16-related protein kinase and negatively regulates organelle fusion at the lysosomal vacuole.Molecular and cellular biology · 2013Article
- Aspergillus nidulans CkiA is an essential casein kinase I required for delivery of amino acid transporters to the plasma membrane.Molecular microbiology · 2012Article
- The yeast Batten disease orthologue Btn1 controls endosome-Golgi retrograde transport via SNARE assembly.The Journal of cell biology · 2011Article
- Dysregulated Arl1, a regulator of post-Golgi vesicle tethering, can inhibit endosomal transport and cell proliferation in yeast.Molecular biology of the cell · 2011Article
- Forebrain overexpression of CK1delta leads to down-regulation of dopamine receptors and altered locomotor activity reminiscent of ADHD.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Versatile casein kinase 1: multiple locations and functions.Plant signaling & behavior · 2009Article
- Genome-wide analysis of AP-3-dependent protein transport in yeast.Molecular biology of the cell · 2009Article
- Arabidopsis casein kinase 1-like 6 contains a microtubule-binding domain and affects the organization of cortical microtubules,.Plant physiology · 2008Article
- The Saccharomyces cerevisiae 60 S ribosome biogenesis factor Tif6p is regulated by Hrr25p-mediated phosphorylation.The Journal of biological chemistry · 2008Article
- Regulation of protein kinase CK1alphaLS by dephosphorylation in response to hydrogen peroxide.Archives of biochemistry and biophysics · 2007Article
- Role for Gcs1p in regulation of Arl1p at trans-Golgi compartments.Molecular biology of the cell · 2005Article
- The vacuolar kinase Yck3 maintains organelle fragmentation by regulating the HOPS tethering complex.The Journal of cell biology · 2005Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
The GCS1 gene of the budding yeast Saccharomyces cerevisiae mediate the resumption of cell proliferation from the starved, stationary-phase state. Here we identify yeast genes that, in increased dosages, overcome the growth defect of gcs1 delta mutant cells. Among these are YCK1 (CK12) and YCK2 (CKI1), encoding membrane-associated casein kinase I, and YCK3, encoding a novel casein kinase I isoform. Some Yck3p gene product was found associated with the plasma membrane, like Yck1p and Yck2p, but most confractionated with the nucleus, like another yeast casein kinase I isoform, Hrr25p. Genetic studies showed that YCK3 and HRR25 constitute an essential gene family and that Yck3p can weakly substitute for Yck1p-Yck2p. For gcs1 delta suppression, both a protein kinase domain and a C-terminal prenylation motif were shown to be necessary. An impairment in endocytosis was found for gcs1 delta mutant cells, which was alleviated by an increased YCK2 gene dosage. The ability of an increased casein kinase I gene dosage to suppress the effects caused by the absence of Gcs1p suggests that Gcs1p and Yck1p-Yck2p affect parallel pathways.
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