ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Basic fibroblast growth factor increases functional L-type Ca2+ channels in fetal rat hippocampal neurons: implications for neurite morphogenesis in vitro.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 61 citations in OpenAlex.
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- Characterization of L-type voltage-gated Ca(2+) channel expression and function in developing CA3 pyramidal neurons.Neuroscience · 2013Article
- Ethanol modulates spontaneous calcium waves in axonal growth cones in vitro.Brain sciences · 2013Article
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- Ethanol alters calcium signaling in axonal growth cones.Neuroscience · 2011Article
- Brain-derived neurotrophic factor promotes the maturation of GABAergic mechanisms in cultured hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Regulation of structural plasticity by different channel types in rod and cone photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Fibroblast growth factor-2 promotes axon branching of cortical neurons by influencing morphology and behavior of the primary growth cone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Sustained activation of hippocampal Lp-type voltage-gated calcium channels by tetanic stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2000Article
- Anomalous L-type calcium channels of rat spinal motoneurons.The Journal of general physiology · 1999Article
- Regulation of ion channel expression in neural cells by hormones and growth factors.Molecular neurobiology · 1998Review
- Differential regulation of potassium currents by FGF-1 and FGF-2 in embryonic Xenopus laevis myocytes.The Journal of physiology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basic fibroblast growth factor (bFGF) is a potent neurotrophic factor that regulates cell proliferation and differentiation during neuronal development. Here we report that fetal hippocampal neurons chronically treated with bFGF displayed larger [Ca2+]i increases than nontreated neurons in response to high K(+)-induced depolarization. This [Ca2+]i response was abolished by nicardipine and was little affected by treatments that depleted intracellular Ca2+ stores, thus reflecting the activities of L-type voltage-dependent Ca2+ channels. Whole-cell recordings also demonstrated increased high-voltage-activated Ca2+ currents in bFGF-treated neurons, whereas low-voltage-activated Ca2+ currents remained unchanged. bFGF-stimulated increase in Ca2+ response was not observed in neurons treated with cycloheximide or actinomycin D, indicating that protein and RNA synthesis were required for this effect. Visualization using a fluorescent dihydropyridine analog revealed that bFGF-treated neurons expressed increased amounts of L-type Ca2+ channels on the cell body. In addition, bFGF-treated neurons acquired distinctive morphology of neurites that was characterized by markedly increased neuritic branching. The branching points in neurites were associated with clusters of L-type Ca2+ channels and resultant "Ca2+ hotspots" that showed large [Ca2+]i increases in response to membrane depolarization. Concurrent application of nicardipine completely blocked the bFGF-stimulated increase in neuritic branching. Therefore, bFGF enhances the expression of functional L-type Ca2+ channels on the cell body and neurites of fetal hippocampal neurons, which may play an important role in the regulation of their differentiation and the establishment of their neurite morphology.
Indexed as
Identifiers
8815926PMC6578905W1873545359What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.