ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Functional diversity of P-type and R-type calcium channels in rat cerebellar neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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Who cites it
58 citing papers in PubMed, 158 citations in OpenAlex.
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- The expression pattern of a Cav3-Kv4 complex differentially regulates spike output in cerebellar granule cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics.Journal of neurophysiology · 2014Article
- Voltage-gated calcium channels.Cold Spring Harbor perspectives in biology · 2011Review
- Ca(2+)-dependent enhancement of release by subthreshold somatic depolarization.Nature neuroscience · 2011Article
- CaV2.1 channelopathies.Pflugers Archiv : European journal of physiology · 2010Review
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- Pharmacological and biophysical properties of Ca2+ channels and subtype distributions in human adrenal chromaffin cells.Pflugers Archiv : European journal of physiology · 2008Article
- Increased expression of golli myelin basic proteins enhances calcium influx into oligodendroglial cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Differential control of two forms of glutamate release by group III metabotropic glutamate receptors at rat entorhinal synapses.Neuroscience · 2007Article
- T-type and L-type Ca2+ conductances define and encode the bimodal firing pattern of vestibulocerebellar unipolar brush cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Maturation of rat cerebellar Purkinje cells reveals an atypical Ca2+ channel current that is inhibited by omega-agatoxin IVA and the dihydropyridine (-)-(S)-Bay K8644.The Journal of physiology · 2007Article
- Characterization of voltage-dependent sodium and calcium channels in mouse pancreatic A- and B-cells.The Journal of physiology · 2006Article
- Specific T-type calcium channel isoforms are associated with distinct burst phenotypes in deep cerebellar nuclear neurons.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
By combining single-channel and whole-cell patch-clamp recordings, we have established the sensitivity to omega-agatoxin IVA and omega-conotoxin MVIIC (SNX-230) of G1, G2, and G3, the three novel non-L-, non-N-type Ca2+ channels characterized previously in rat cerebellar granule cells. G1 channels were blocked irreversibly by both omega-conotoxin MVIIC and low doses of omega-agatoxin IVA (saturation at 50 nM). Thus, according to pharmacological criteria, G1 channels must be classified as P-type Ca2+ channels. Being slowly inactivating during depolarizing pulses and completely inactivated at voltages in which steady-state inactivation of P-type channels in Purkinje cells is negligible, G1 represents a novel P subtype. Neither G2 nor G3 was blocked irreversibly by omega-conotoxin MVIIC, and therefore both are R-type Ca2+ channels. G2 and G3 have some biophysical properties similar to those of low-voltage-activated (LVA) Ca2+ channels (e.g., voltage range for steady-state inactivation, V 1/2 = -90 mV), some properties similar to those of high-voltage-activated (HVA) Ca2+ channels (e.g., high sensitivity to Cd2+ block), and other properties intermediate between those of LVA and HVA Ca2+ channels, with LVA properties prevailing in G2 and HVA properties prevailing in G3. The R-type whole-cell current was inhibited by Ni2+ with a biphasic dose-response curve (IC50: 4 and 153 microM), suggesting that G2 and G3 may have a different sensitivity to Ni2+ block. Our results uncover functional diversity of both native P-type and R-type Ca2+ channels and show that R subtypes with distinct biophysical properties are coexpressed in rat cerebellar granule cells.
Indexed as
Identifiers
8815914PMC6578912W2140318655What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.