ArticleJournal of muscle research and cell motility1996
Intra-and intercellular calcium waves in cultured human myometrium.
Article in Journal of muscle research and cell motility, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 35 citations in OpenAlex.
- The Effect of Gap Junctional Coupling on the Spatiotemporal Patterns of Ca2+ Signals and the Harmonization of Ca2+-Related Cellular Responses.PLoS computational biology · 2016Article
- Single-cell mechanics and calcium signalling in organotypic slices of human myometrium.Journal of biomechanics · 2015Article
- Characterization of the tissue-level Ca2+ signals in spontaneously contracting human myometrium.Journal of cellular and molecular medicine · 2012Article
- The signaling mechanisms of long distance intercellular calcium waves (far waves) in cultured human uterine myocytes.Journal of muscle research and cell motility · 2002Article
- Coordinated intercellular calcium waves induced by noradrenaline in rat hepatocytes: dual control by gap junction permeability and agonist.The EMBO journal · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular calcium waves were observed in cultured human myometrium using confocal laser scanning microscopy in the epifluorescence mode. Intracellular calcium waves were observed following stimulation of the cells with 10 mU ml-1 oxytocin in physiological bathing solution, or following substitution of tetraethylammonium chloride for NaCl. Intracellular wave speeds were 18.9 +/- 8.2 microns s-1 in physiological bathing solution. Intracellular calcium waves were also observed in cells bathed in calcium-free solutions, with no significant differences in wave speeds. Calcium waves that crossed cell boundaries were also observed. Some intercellular calcium waves travelled large distances (> 500 microns). Wave speeds for intercellular waves were 7.8 +/- 1.6 microns s-1. Attempts to use octanol to determine the contribution of gap junctions to intercellular calcium wave propagation were unsuccessful because of direct effects of 2 mM octanol on calcium oscillations. These data demonstrate that intra- and intercellular calcium waves are a means of tissue level communication in myometrium that is distinct from action potentials with regard to mechanisms of action, propagation speeds, responses to stimuli, and responses to inhibitors.
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Registered trials
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