ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]1996
Failure of L-NAME to cause inhibition of nitric oxide synthesis: role of inducible nitric oxide synthase.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Aged garlic therapeutic intervention targeting inflammatory pathways in pathogenesis of bowel disorders.Heliyon · 2024Article
- Impact of ovary-intact menopause in a mouse model of heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024Article
- Selective gene expression profiling contributes to a better understanding of the molecular pathways underlying the histological changes observed after RHMVL.BMC medical genomics · 2022Article
- Modulation of peroxynitrite produced via mitochondrial nitric oxide synthesis during CaBiochimica et biophysica acta. Bioenergetics · 2020Article
- Calmodulin inhibition as a mode of action of antifungal imidazole pharmaceuticals in non-target organisms.Toxicology research · 2020Article
- Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia.Scientific reports · 2020Article
- Effects of Acetaminophen on Left Atrial Contractility.Acta Cardiologica Sinica · 2016Article
- Involvement of inducible nitric oxide synthase in radiation-induced vascular endothelial damage.Journal of radiation research · 2013Article
- Late-life enalapril administration induces nitric oxide-dependent and independent metabolic adaptations in the rat skeletal muscle.Age (Dordrecht, Netherlands) · 2013Article
- Nitric oxide in asthma physiopathology.ISRN allergy · 2011Article
- The estrogen effects on endothelial repair and mitogen-activated protein kinase activation are abolished in endothelial nitric-oxide (NO) synthase knockout mice, but not by NO synthase inhibition by N-nitro-L-arginine methyl ester.The American journal of pathology · 2008Article
- The nitric oxide-cGMP signaling pathway differentially regulates presynaptic structural plasticity in cone and rod cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Elevation of nitric oxide production in human trabecular meshwork by increased pressure.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2003Article
- Nitric oxide mediates apoptosis through formation of peroxynitrite and Fas/Fas-ligand interactions in experimental autoimmune uveitis.The American journal of pathology · 2002Article
- Dexamethasone worsens nitric oxide inhibition-induced hypertension and renal dysfunction.American journal of hypertension · 2000Article
- Review
- L-NAME causes antinociception by stimulation of the arginine-NO-cGMP pathway.Mediators of inflammation · 2000Article
- Guinea pig model of Mycobacterium tuberculosis latent/dormant infection.Microbes and infectionArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We addressed the hypothesis that administration of nitric oxide synthase inhibitor, NG -nitro-L-arginine methyl ester (L-NAME) does not result in a sustained suppression of nitric oxide (NO) synthesis, because of a compensatory expression of inducible nitric oxide synthase (iNOS). L-NAME was administered in the drinking water (0.1-1.0 mg/ml) for 7 days to guinea pigs and rats. Nitric oxide synthesis was assessed by [1] ex vivo formation of nitrite in blood vessels and intestine [2] tissue levels of cGMP [3] iNOS gene expression by RT-PCR [4] NADPH diaphorase staining [5] direct assessment of NO release in tissue explants using a microelectrode/electrochemical detection system. Chronic L-NAME administration elevated intestinal cGMP and nitrite levels in guinea pigs (p < 0.05). In rats, intestinal nitrite levels were comparable in control and L-NAME treatment groups, whereas direct assessment of NO release defined a marked increase in the L-NAME group. Chronic L-NAME resulted in an induction of iNOS gene expression in rats and guinea pigs and novel sites of NADPH diaphorase staining in the intestine. We conclude that iNOS expression is responsible for a compensatory increase or normalization of NO synthesis during sustained administration of L-NAME.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.