Evidence map›Paper›PMID 8813951›Full record

ArticleJournal of clinical pathology1996

Proliferation indexes--a comparison between cutaneous basal and squamous cell carcinomas.

M H al-Sader, E Doyle, E W Kay, M Bennett, C B Walsh, B Curran, C Milburn, M Leader

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Journal of clinical pathology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

M H al-SaderDepartment of Pathology, Royal College of Surgeons in Ireland, Dublin 2, Ireland.
E Doyle
E W Kay
M Bennett
C B Walsh
B Curran
C Milburn
M Leader

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo compare differences in cell proliferation indexes and apoptotic indexes between cutaneous basal and squamous cell carcinomas, in an attempt to suggest an explanation for the differences in their biological behaviour.

methodsForty cases of cutaneous basal cell carcinoma (BCC) and 40 cases of moderately and well differentiated squamous cell carcinoma (SCC) were retrieved from the archives. Sections, 4 microns thick, were cut from formalin fixed, paraffin wax embedded tissue in each case and stained with haematoxylin and eosin. These were then examined for mitotic and apoptotic figures per 1000 cells. Sections from the same cases were also immunostained with the mouse monoclonal antibody Ki67 (MIB1); positive nuclear staining was counted per 1000 cells.

resultsNo significant differences were found between the mitotic indexes and apoptotic indexes in these tumours. There was, however, a significant difference in Ki67 (MIB1) staining, with greater staining in the squamous cell carcinomas.

conclusionEstimation of the mitotic and apoptotic indexes did not reveal any differences between these two tumour types. The proliferation indexes, assessed by Ki67 immunostaining, did differ. This may be one of the factors underlying the more aggressive behaviour of SCC.

Indexed as

Cell DivisionApoptosisBasal Cell CarcinomaCarcinoma, Squamous CellHumansImmunohistochemistryMitotic IndexSkin Neoplasms

Identifiers

PMID8813951
PMCPMC500567

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