ArticleBMJ (Clinical research ed.)1996
Serum cholesterol concentration and death from suicide in men: Paris prospective study I.
Article in BMJ (Clinical research ed.), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 4 of them syntheses that pooled it.
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Who cites it
43 citing papers in PubMed, 4 syntheses or guidelines pooled it, 151 citations in OpenAlex.
- Biological risk factors for suicidal behaviors: a meta-analysis.Translational psychiatry · 2016Pooled it
- Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies.Journal of psychiatry & neuroscience : JPN · 2016Pooled it
- The impact of statins on psychological wellbeing: a systematic review and meta-analysis.BMC medicine · 2012Pooled it
- Cholesterol reduction and non-illness mortality: meta-analysis of randomised clinical trials.BMJ (Clinical research ed.) · 2001Pooled it
- Effects of 28-day simvastatin administration on emotional processing, reward learning, working memory, and salivary cortisol in healthy participants at-risk for depression: OxSTEP, an online experimental medicine trial.Psychological medicine · 2025Trial
- The use of statins for the treatment of depression in patients with acute coronary syndrome.Translational psychiatry · 2015Trial
- Mortality and adverse events associated with statin use in primary care patients with depression: a real-world, population-based cohort study.BMJ mental health · 2024Article
- Statin-induced increase in actin polymerization modulates GPCR dynamics and compartmentalization.Biophysical journal · 2023Article
- Age-specific associations between serum cholesterol levels and suicidal behaviors in patients with depressive disorders: A naturalistic prospective observational cohort study.Frontiers in psychiatry · 2023Article
- The Relationships between Abnormal Serum Lipid Levels, Depression, and Suicidal Ideation According to Sex.Journal of clinical medicine · 2022Article
- Nutritional status and eating habits of people who use drugs and/or are undergoing treatment for recovery: a narrative review.Nutrition reviews · 2021Review
- Toward a Biosignature of Suicide Reattempt.Current topics in behavioral neurosciences · 2020Article
- Low cholesterol is not always good: low cholesterol levels are associated with decreased serotonin and increased aggression in fish.Biology open · 2018Article
- Prevalence of hypobetalipoproteinemia and related psychiatric characteristics in a psychiatric population: results from the retrospective HYPOPSY Study.Lipids in health and disease · 2018Article
- Therapeutic Strategies for Treatment of Inflammation-related Depression.Current neuropharmacology · 2018Review
- Hypocholesterolemia is an independent risk factor for depression disorder and suicide attempt in Northern Mexican population.BMC psychiatry · 2018Article
- Neuropsychological state of the population living in the Aral Sea region (zone of ecological crisis).International journal of occupational and environmental health · 2017Article
- The Role of Lipid Biomarkers in Major Depression.Healthcare (Basel, Switzerland) · 2017Review
- Is low total cholesterol levels associated with suicide attempt in depressive patients?Annals of general psychiatry · 2017Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate whether low serum cholesterol concentration or changing serum cholesterol concentration is associated with risk of suicide in men.
designCohort study with annual repeat measurements of serum cholesterol concentration (for up to four years).
settingParis, France. SUBJECTS: 6393 working men, aged 43-52 in 1967-72, who had at least three measurements of serum cholesterol concentration.
main outcome measuresIndividual change over time in serum cholesterol concentration (estimated using within person linear regression method); death from suicide during average of 17 years' follow up after last examination.
results32 men committed suicide during follow up. After adjustment for age and other factors, relative risk of suicide for men with low average serum cholesterol concentration (< 4.78 mmol/l) compared with those with average serum cholesterol concentration of 4.78-6.21 mmol/l was 3.16 (95% confidence interval 1.38 to 7.22, P = 0.007). Men whose serum cholesterol concentration decreased by more than 0.13 mmol/l a year had multivariate adjusted relative risk of 2.17 (0.97 to 4.84, P = 0.056) compared with those whose cholesterol remained stable (change of < or = 0.13 mmol/l a year).
conclusionBoth low serum cholesterol concentration and declining cholesterol concentration were associated with increased risk of death from suicide in men. Although there is some evidence in favour of a concomitant rather than a causal effect for interpreting these associations, long term surveillance of subjects included in trials of lipid lowering treatments seems warranted.
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