ArticleMedical microbiology and immunology1996
Expression of both M protein and hyaluronic acid capsule by group A streptococcal strains results in a high virulence for chicken embryos.
Article in Medical microbiology and immunology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 44 citations in OpenAlex.
- The Superiority ofMicroorganisms · 2022Article
- PRD-Containing Virulence Regulators (PCVRs) in Pathogenic Bacteria.Frontiers in cellular and infection microbiology · 2021Review
- Capsular Polysaccharide of Group AMicrobiology spectrum · 2019Article
- StreptoBase: An Oral Streptococcus mitis Group Genomic Resource and Analysis Platform.PloS one · 2016Article
- covR Mediated Antibiofilm Activity of 3-Furancarboxaldehyde Increases the Virulence of Group A Streptococcus.PloS one · 2015Article
- Article
- Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection.Eukaryotic cell · 2007Article
- Phosphorylation of the group A Streptococcal CovR response regulator causes dimerization and promoter-specific recruitment by RNA polymerase.Journal of bacteriology · 2006Article
- Mga is sufficient to activate transcription in vitro of sof-sfbX and other Mga-regulated virulence genes in the group A Streptococcus.Journal of bacteriology · 2006Article
- Pathogenesis of group A streptococcal infections.Clinical microbiology reviews · 2000Review
- Production of stabilized virulence factor-negative variants by group A streptococci during stationary phase.Infection and immunity · 1998Article
- Conversion of M serotype 24 of Streptococcus pyogenes to M serotypes 5 and 18: effect on resistance to phagocytosis and adhesion to host cells.Infection and immunity · 1997Article
- Hyaluronic acid capsule and the role of streptococcal entry into keratinocytes in invasive skin infection.The Journal of clinical investigation · 1996Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human pathogenic microorganism Streptococcus pyogenes can resist against phagocytic attack of human granulocytes. Streptococcal M protein and hyaluronic acid were identified as virulence factors involved in this protection. So far, no experiments have been reported which describe the contribution of both components together in one system. We used the chicken embryo as an in vivo phagocytosis model to investigate the role of both components on the virulence of streptococci. For this, isogeneic mutants of group A streptococcal strains (GAS) which lack hyaluronic acid capsule (cap-) or M protein (M-) expression were used for infection and their virulence was compared with laboratory strains which had lost their ability to produce one or both virulence factors after long-time laboratory passages on blood agar. The experiments revealed that strains producing both M protein and hyaluronic capsule were highly virulent. Only 1-10 colony-forming units were enough to cause a 50% lethality of 12-day-old chicken embryos. Those strains lacking one of these components showed a significant decrease in virulence. Finally, strains which failed to express either hyaluronic acid or M protein showed an additional tenfold decrease in virulence. This indicates a partial contribution of both M protein and hyaluronic acid to the virulence of GAS in the chicken embryo.
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