ArticleNucleic acids research1996
Utilization of the same DNA replication origin by human cells of different derivation.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Origins of DNA replication in eukaryotes.Molecular cell · 2023Review
- Peaks cloaked in the mist: the landscape of mammalian replication origins.The Journal of cell biology · 2015Review
- Differential chromatin structure encompassing replication origins in transformed and normal cells.Genes & cancer · 2012Article
- Tissue- and age-specific DNA replication patterns at the CTG/CAG-expanded human myotonic dystrophy type 1 locus.Nature structural & molecular biology · 2010Article
- Increased origin activity in transformed versus normal cells: identification of novel protein players involved in DNA replication and cellular transformation.Nucleic acids research · 2010Article
- Transient dsDNA breaks during pre-replication complex assembly.Nucleic acids research · 2009Article
- Mapping of DNA replication origins to noncoding genes of the X-inactivation center.Molecular and cellular biology · 2006Article
- Defined sequence modules and an architectural element cooperate to promote initiation at an ectopic mammalian chromosomal replication origin.Molecular and cellular biology · 2004Article
- Long-term transgene expression in proliferating cells mediated by episomally maintained high-capacity adenovirus vectors.Journal of virology · 2004Article
- Developmentally regulated usage of Physarum DNA replication origins.EMBO reports · 2003Article
- Site-specific and temporally controlled initiation of DNA replication in a human cell-free system.Nucleic acids research · 2002Article
- Multiple sites of replication initiation in the human beta-globin gene locus.Nucleic acids research · 2001Article
- The Chinese hamster dihydrofolate reductase replication origin beta is active at multiple ectopic chromosomal locations and requires specific DNA sequence elements for activity.Molecular and cellular biology · 2001Article
- Differential activity of two non-hr origins during replication of the baculovirus Autographa californica nuclear polyhedrosis virus genome.Journal of virology · 2000Article
- Activity of the c-myc replicator at an ectopic chromosomal location.Molecular and cellular biology · 1999Article
- Concurrent replication and methylation at mammalian origins of replication.Molecular and cellular biology · 1998Article
- Cell cycle modulation of protein-DNA interactions at a human replication origin.The EMBO journal · 1998Article
- oriGNAI3: a narrow zone of preferential replication initiation in mammalian cells identified by 2D gel and competitive PCR replicon mapping techniques.Nucleic acids research · 1998Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the past, a highly sensitive and efficient method was developed to map DNA replication origins in human cells, based on quantitative PCR performed on nascent DNA samples. This method allowed the identification of a replication origin in the myeloid HL-60 cell line, located on chromosome 19 within an approximately 500 bp segment near the lamin B2 gene [Giacca et al. (1994) Proc. Natl. Acad. Sci. USA, 91, 7119]. The same procedure has now been further simplified and extended to a variety of other exponentially growing human cells of different histological derivation (three neural, one connectival and one epithelial), with a nearly diploid chromosomal content. In all the six cell lines tested, the origin activity within the lamin B2 gene domain was localized to the same region. Furthermore, the lamin B2 origin was also found to be active in stimulated, but not in quiescent, peripheral blood lymphocytes.
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