Evidence map›Paper›PMID 8808606›Full record

ArticleAmerican journal of human genetics1996

Analysis of meiotic segregation, using single-sperm typing: meiotic drive at the myotonic dystrophy locus.

E P Leeflang, M S McPeek, N Arnheim

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of human genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability.Proceedings of the National Academy of Sciences of the United States of America · 1998
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

E P LeeflangDepartment of Biological Sciences, Molecular Biology Program, University of Southern California, Los Angeles, USA.
M S McPeek
N Arnheim
University of Southern California · US

Funding

GENETICS STUDIES USING SPERM TYPINGR37GM036745 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ARNHEIM, NORMAN · 1992 to 2001
$1.5M
NIGMS NIH HHS R37GM36745
6 · The paper itself

Abstract

Meiotic drive at the myotonic dystrophy (DM) locus has recently been suggested as being responsible for maintaining the frequency, in the human population, of DM chromosomes capable of expansion to the disease state. In order to test this hypothesis, we have studied samples of single sperm from three individuals heterozygous at the DM locus, each with one allele larger and one allele smaller than 19 CTG repeats. To guard against the possible problem of differential PCR amplification rates based on the lengths of the alleles, the sperm were also typed at another closely linked marker whose allele size was unrelated to the allele size at the DM locus. Using statistical models specifically designed to study single-sperm segregation data, we find no evidence of meiotic segregation distortion. The upper limit of the two-sided 95% confidence interval for the estimate of the common segregation probability for the three donors is at or below .515 for all models considered, and no statistically significant difference from .5 is detected in any of the models. This suggests that any greater amount of segregation distortion at the myotonic dystrophy locus must result from events following sperm ejaculation. The mathematical models developed make it possible to study segregation distortion with high resolution by using sperm-typing data from any locus.

Indexed as

MeiosisAdultAllelesGenetic Carrier ScreeningHumansMaleModels, BiologicalMyotonic DystrophyPolymerase Chain ReactionSpermatozoa

Identifiers

PMID8808606
PMCPMC1914809
OpenAlexW1531485638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.