ArticleJournal of gastroenterology1996
Expression of CD10/neutral endopeptidase in normal and malignant tissues of the human stomach and colon.
Article in Journal of gastroenterology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 95 citations in OpenAlex.
- Article
- Predictive role of neostromal CD10 expression in breast cancer patients treated with neoadjuvant chemotherapy.Pathology oncology research : POR · 2022Article
- Evaluation of CD10 expression as a diagnostic marker for colorectal cancer.Gastroenterology and hepatology from bed to bench · 2022Article
- Neutral endopeptidase depletion decreases colon cancer cell proliferation and TGF-β1 synthesis in indirect co-cultures with normal colon fibroblasts.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2021Article
- Spinal Versus Intracranial Meningioma: Aberrant Expression of CD10 and Inhibin with Relation to Clinicopathological Features and Prognosis.Pathology oncology research : POR · 2020Article
- Stromal CD10 expression in breast cancer correlates with tumor invasion and cancer stem cell phenotype.BMC cancer · 2018Article
- Neutral endopeptidase (NEP) is differentially involved in biological activities and cell signaling of colon cancer cell lines derived from various stages of tumor development.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Fukutin, identified by the Escherichia coli ampicillin secretion trap (CAST) method, participates in tumor progression in gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2016Article
- Role of B Cell Development Marker CD10 in Cancer Progression and Prognosis.Molecular biology international · 2016Review
- In Vivo Stabilization of a Gastrin-Releasing Peptide Receptor Antagonist Enhances PET Imaging and Radionuclide Therapy of Prostate Cancer in Preclinical Studies.Theranostics · 2016Article
- Opioids, Neutral Endopeptidase, its Inhibitors and Cancer: Is There a Relationship among them?Archivum immunologiae et therapiae experimentalis · 2015Review
- Prognostic significance of the combined expression of neutral endopeptidase and dipeptidyl peptidase IV in intrahepatic cholangiocarcinoma patients after surgery resection.OncoTargets and therapy · 2014Article
- Loss of gastric gland mucin-specific O-glycan is associated with progression of differentiated-type adenocarcinoma of the stomach.Cancer science · 2014Article
- The contribution of cell phenotype to the behavior of gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2013Article
- Myeloid cells positive for CD10 at invasion front can predict poor outcome in stage II colorectal cancer.International journal of clinical oncology · 2012Article
- CD10 expression in epithelial and stromal cells of non-small cell lung carcinoma (NSCLC): a clinic and pathologic correlation.Pathology oncology research : POR · 2012Article
- Prognostic role of CD10⁺ myeloid cells in association with tumor budding at the invasion front of colorectal cancer.Cancer science · 2011Article
- Role of neurokinin-1 receptor in the initiation and maintenance of skin chronic inflammatory diseases.Immunologic research · 2011Article
- Candidate biomarkers in exosome-like vesicles purified from rat and mouse urine samples.Proteomics. Clinical applications · 2010Article
- CD10 expression in urothelial carcinoma of the bladder.Diagnostic pathology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expression of common acute lymphoblastic leukemia antigen (CALLA; CD10), which is identical to neutral endopeptidase (NEP, EC3.424.11), was examined in the malignant and adjacent noninvaded tissues of the human stomach and colon (n = 27). All of 27 normal and 18 well or moderately differentiated adenocarcioma tissue specimens were positive for monoclonal antibody (mAb) NL-1 against CD10/NEP, whereas the expression level was clearly decreased in all of 9 specimens of poorly differentiated adenocarcinoma. In addition, all of 7 gastric or colorectal carcinoma cell lines tested showed decreased expression of CD10/NEP. Sodium dodecylsulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot analysis of the crude antigen J5 from the normal colon tissue lysate by mAb J5 detected a single band of approximately 100 kDa that was consistent with that of NALM-6 cells used as a positive control. These findings suggest that CD10/NEP is expressed in normal epithelial cells of the human stomach and colon, whereas the expression level is decreased in the poorly differentiated type of adenocarcinoma.
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