ArticleGenetics1996
Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 129 citations in OpenAlex.
- Insulin receptor substrate family member IST-1 regulates the development ofmicroPublication biology · 2025Article
- Genetic basis of enhanced stress resistance in long-lived mutants highlights key role of innate immunity in determining longevity.Aging cell · 2023Article
- Article
- Career Retrospective: Tom Johnson-Genetics, Genomics, Stress, Stochastic Variation, and Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Starvation Responses Throughout theGenetics · 2020Review
- DAF-16/FoxO inCells · 2020Review
- The Mechanism of Programmed Aging: The Way to Create a Real Remedy for Senescence.Current aging science · 2020Review
- BRAP-2 promotes DNA damage induced germline apoptosis in C. elegans through the regulation of SKN-1 and AKT-1.Cell death and differentiation · 2018Article
- Opposing roles of microRNA Argonautes during Caenorhabditis elegans aging.PLoS genetics · 2018Article
- A Bystander Mechanism Explains the Specific Phenotype of a Broadly Expressed Misfolded Protein.PLoS genetics · 2016Article
- Fluorescent Beads Are a Versatile Tool for Staging Caenorhabditis elegans in Different Life Histories.G3 (Bethesda, Md.) · 2016Article
- The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster.BMB reports · 2016Review
- Light and pheromone-sensing neurons regulates cold habituation through insulin signalling in Caenorhabditis elegans.Nature communications · 2014Article
- A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication.Development (Cambridge, England) · 2014Article
- Stressful environments can indirectly select for increased longevity.Ecology and evolution · 2014Article
- Caenorhabditis elegans: A useful model for studying metabolic disorders in which oxidative stress is a contributing factor.Oxidative medicine and cellular longevity · 2014Review
- The unfolded protein response in a pair of sensory neurons promotes entry of C. elegans into dauer diapause.Current biology : CB · 2013Article
- A cytoprotective perspective on longevity regulation.Trends in cell biology · 2013Review
- Femtosecond laser ablation reveals antagonistic sensory and neuroendocrine signaling that underlie C. elegans behavior and development.Cell reports · 2013Article
- TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.PLoS genetics · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Based on environmental cues, the nervous system of Caenorhabditis elegans regulates formation of the dauer larva, an alternative larval form specialized for long-term survival under harsh conditions. Mutations that cause constitutive or defective dauer formation (Daf-c or Daf-d) have been identified and the genes ordered in a branched pathway. Most Daf-c mutations also affect recovery from the dauer stage. The semi-dominant mutation daf-28(sa191) is Daf-c but has no apparent effect on dauer recovery. We use this unique aspect of daf-28(sa191) to characterize the effects of several Daf-d and synthetic Daf-c mutations on dauer recovery. We present double mutant analysis that indicates that daf-28(sa191) acts at a novel point downstream in the genetic pathway for dauer formation. We also show that daf-28(sa191) causes a modest increase (12-13%) in life span. The phenotypes and genetic interactions of daf-28(sa191) are most similar to those of daf-2 and daf-23 mutations, which also cause a dramatic increase in life span. We present mapping and complementation data that suggest that daf-23 is the same gene as age-1, identified previously by mutations that extend life span. We find that age-1 alleles are also Daf-c at 27 degrees.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.