ArticleBiophysical journal1996
Theoretical estimates of mechanical properties of the endothelial cell cytoskeleton.
Article in Biophysical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed.
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- Anti-endothelial cell antibodies in pathogenesis of vasculitis.Frontiers in immunology · 2025Review
- On the role of myosin-induced actin depolymerization during cell migration.Molecular biology of the cell · 2023Article
- Study of the Effect of Cell Prestress on the Cell Membrane Penetration Behavior by Atomic Force Microscopy.Micromachines · 2023Article
- Elasticity of podosome actin networks produces nanonewton protrusive forces.Nature communications · 2022Article
- Effective Force Generation During Mammalian Cell Migration Under Different Molecular and Physical Mechanisms.Frontiers in cell and developmental biology · 2022Article
- Blood vessel-on-a-chip examines the biomechanics of microvasculature.Soft matter · 2021Article
- In silico stress fibre content affects peak strain in cytoplasm and nucleus but not in the membrane for uniaxial substrate stretch.Medical & biological engineering & computing · 2021Article
- Dynamic cellular biomechanics in responses to chemotherapeutic drug in hypoxia probed by atomic force spectroscopy.Oncotarget · 2021Article
- Anomalous mechanics of ZnProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Altered mechanical properties of actin fibers due to breast cancer invasion: parameter identification based on micropipette aspiration and multiscale tensegrity modeling.Medical & biological engineering & computing · 2021Article
- Effects of Lipid Deposition on Viscoelastic Response in Human Hepatic Cell Line HepG2.Frontiers in physiology · 2021Article
- VIP Stabilizes the Cytoskeleton of Schlemm's Canal Endothelia via Reducing Caspase-3 Mediated ZO-1 Endolysosomal Degradation.Oxidative medicine and cellular longevity · 2021Article
- Recent Advances on the Model, Measurement Technique, and Application of Single Cell Mechanics.International journal of molecular sciences · 2020Review
- Symmetry breaking in hydrodynamic forces drives meiotic spindle rotation in mammalian oocytes.Science advances · 2020Article
- Actin assembly produces sufficient forces for endocytosis in yeast.Molecular biology of the cell · 2019Article
- Transition from Actin-Driven to Water-Driven Cell Migration Depends on External Hydraulic Resistance.Biophysical journal · 2018Article
- The Role of Network Architecture in Collagen Mechanics.Biophysical journal · 2018Article
- Simulation of actin distribution of osteoblasts on titanium pillar arrays using a bio-chemo-mechanical model.International journal for numerical methods in biomedical engineering · 2018Article
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2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Current modeling of endothelial cell mechanics does not account for the network of F-actin that permeates the cytoplasm. This network, the distributed cytoplasmic structural actin (DCSA), extends from apical to basal membranes, with frequent attachments. Stress fibers are intercalated within the network, with similar frequent attachments. The microscopic structure of the DCSA resembles a foam, so that the mechanical properties can be estimated with analogy to these well-studied systems. The moduli of shear and elastic deformations are estimated to be on the order of 10(5) dynes/cm2. This prediction agrees with experimental measurements of the properties of cytoplasm and endothelial cells reported elsewhere. Stress fibers can potentially increase the modulus by a factor of 2-10, depending on whether they act in series or parallel to the network in transmitting surface forces. The deformations produced by physiological flow fields are of insufficient magnitude to disrupt cell-to-cell or DCSA cross-linkages. The questions raised by this paradox, and the ramifications of implicating the previously unreported DCSA as the primary force transmission element are discussed.
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