ReviewCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne1996
Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: a review of spontaneous reports.
Review in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 59 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 291 citations in OpenAlex.
- The risk of hyponatremia induced by SSRIs and SNRIs antidepressants: a systematic review and meta-analysis.BMC pharmacology & toxicology · 2025Pooled it
- Generalised anxiety disorder.BMJ clinical evidence · 2011Pooled it
- Comparative risk for harms of second-generation antidepressants : a systematic review and meta-analysis.Drug safety · 2008Pooled it
- Generalised anxiety disorder.BMJ clinical evidence · 2007Pooled it
- Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age-Related Fluoxetine Accumulation in the Elderly.CPT: pharmacometrics & systems pharmacology · 2026Article
- Article
- Article
- Possible Cognitive Dysfunction Associated With High-Dose Fluoxetine in a Patient on Lithium.Case reports in psychiatry · 2026Article
- The interplay between serotonin syndrome and syndrome of inappropriate antidiuresis: a fatal case of acute hyponatremia during treatment with duloxetine, chlorphenamine, amitriptyline, and L-tryptophan.Therapeutic advances in psychopharmacology · 2026Article
- Case Report: Severe SIADH and QTc prolongation induced by escitalopram-quetiapine interaction in a CYP2C19 intermediate metabolizer at therapeutic doses.Frontiers in pharmacology · 2026Article
- A drug-based model to predict hyponatremia in outpatients of a geriatric clinic.European journal of clinical pharmacology · 2025Article
- Drug-Induced Cognitive Impairment.Drug safety · 2025Review
- Article
- Psychological and Psychopharmacological Interventions in Psychocardiology.Frontiers in psychiatry · 2022Review
- Factors Associated with Hyponatremia in Patients Newly Prescribed Citalopram: A Retrospective Observational Study.Drugs - real world outcomes · 2021Article
- Management of SIADH-related hyponatremia due to psychotropic medications - An expert consensus from the Association of Medicine and Psychiatry.Journal of psychosomatic research · 2021Article
- Psychotropic drug-induced hyponatremia: results from a drug surveillance program-an update.Journal of neural transmission (Vienna, Austria : 1996) · 2021Article
- Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Induced by Long-Term Use of Citalopram and Short-Term Use of Naproxen.The American journal of case reports · 2020Article
- Article
- Olanzapine-Induced Hyponatremia Presenting with Seizure Requiring Intensive Care Unit Admission.Cureus · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo review reported cases of hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) associated with the use of selective serotonin reuptake inhibitors (SSRIs). DATA SOURCES: A search of MEDLINE for reports of hyponatremia and SIADH associated with the use of fluoxetine, fluvoxamine, paroxetine or sertraline published between January 1980 and May 1995. Unpublished reports of cases were requested from the pharmaceutical industry, the Ontario Medical Association, the Health Protection Branch of Health Canada, the US Food and Drug Administration and the World Health Organization. DATA SELECTION AND EXTRACTION: Spontaneous reports from postmarketing surveillance. DATA SYNTHESIS: A total of 736 cases of hyponatremia [corrected] and SIADH associated with SSRI use were reported. Fluoxetine was involved in 554 (75.3%) of the cases, paroxetine in 91 (12.4%), sertraline in 86 (11.7%) and fluvoxamine in 11 (1.5%). Reports of 30 cases were published. The remaining 706 cases were reported to monitoring bodies and the pharmaceutical industry. According to information in the published reports, the median time to onset of hyponatremia was 13 days (range 3 to 120 days). Most (83%) of the published cases involved patients 65 years of age or more, as compared with 74% of the unpublished cases.
conclusionElderly people may be at increased risk for hyponatremia associated with SSRI use. Physicians caring for elderly patients should be aware of this potentially serious but reversible adverse effect. Further research is required to determine the incidence of this adverse effect, the relative risk of hyponatremia and SIADH in different age groups and the risk associated with different SSRI drugs.
Indexed as
Identifiers
8804257PMC1335030W1761014261What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.