ReviewMicrobiological reviews1996
Artemisinin and the antimalarial endoperoxides: from herbal remedy to targeted chemotherapy.
Review in Microbiological reviews, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 5 syntheses or guidelines pooled it, 580 citations in OpenAlex.
- Phosphorylation in theJournal of proteome research · 2024Pooled it
- Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria.The Cochrane database of systematic reviews · 2014Pooled it
- Artemisinin-based combination therapy for treating uncomplicated malaria.The Cochrane database of systematic reviews · 2009Pooled it
- Artemisinin derivatives for treating severe malaria.The Cochrane database of systematic reviews · 2000Pooled it
- Artemisinin derivatives for treating uncomplicated malaria.The Cochrane database of systematic reviews · 2000Pooled it
- Trial
- First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials.British journal of clinical pharmacology · 2013Trial
- The pharmacokinetics of intravenous artesunate in adults with severe falciparum malaria.European journal of clinical pharmacology · 2006Trial
- Artemisinin pharmacokinetics and efficacy in uncomplicated-malaria patients treated with two different dosage regimens.Antimicrobial agents and chemotherapy · 2002Trial
- Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria.Antimicrobial agents and chemotherapy · 2000Trial
- Synthesis, Structure, and Antileishmanial Activity of Novel 1,2,4-Trioxolanes, 1,2,4,5-Tetraoxanes and Their Respective Deoxygenated Controls.ChemMedChem · 2026Article
- Why are iron chelators not as effective as artemisinin in killing malaria parasites?Parasites & vectors · 2026Article
- Article
- Bioactive constituents from the edible seaweedPharmaceutical biology · 2025Article
- An updated survey on the recent advancement of antimalarial molecules: synthetic methodologies and SAR studies.Molecular diversity · 2025Review
- Hybrid Molecules as Efficient Drugs against Multidrug-Resistant Malaria Parasites.ChemMedChem · 2025Review
- Solidified reverse micellar solution-based chitosan-coated solid lipid nanoparticles as a new approach to enhance oral delivery of artemether in malaria treatment.BMC chemistry · 2025Article
- Emerging trends and new developments in global research on artemisinin and its derivatives.Heliyon · 2025Article
- A TetR family regulator of an RND efflux system that directs artemisinin resistance inmSystems · 2024Article
- Voltammetric methods for electrochemical characterization and quantification of artemether-based antimalarials.Analytical methods : advancing methods and applications · 2024Article
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artemisinin and its derivatives are endoperoxide-containing compounds which represent a promising new class of antimalarial drugs. In the presence of intraparasitic iron, these drugs are converted into free radicals and other electrophilic intermediates which then alkylate specific malaria target proteins. Combinations of available derivatives and other antimalarial agents show promise both as first-line agents and in the treatment of severe disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.