ArticleAnatomy and embryology1996
Expression of Fgf-3 in relation to hindbrain segmentation, otic pit position and pharyngeal arch morphology in normal and retinoic acid-exposed mouse embryos.
Article in Anatomy and embryology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 90 citations in OpenAlex.
- Dual-patterned pluripotent stem cells self-organize into a human embryo model with extended anterior-posterior patterning.bioRxiv : the preprint server for biology · 2025Article
- A journey in the world of craniofacial development: From 1968 to the future.Journal of anatomy · 2024Review
- Shared features in ear and kidney development - implications for oto-renal syndromes.Disease models & mechanisms · 2024Article
- Zbtb16 mediates a switch between Fgf signalling regimes in the developing hindbrain.Development (Cambridge, England) · 2023Article
- Hindbrain induction and patterning during early vertebrate development.Cellular and molecular life sciences : CMLS · 2019Review
- Fgf3 and Fgf16 expression patterns define spatial and temporal domains in the developing chick inner ear.Brain structure & function · 2017Article
- A new role of hindbrain boundaries as pools of neural stem/progenitor cells regulated by Sox2.BMC biology · 2016Article
- Signaling in cell differentiation and morphogenesis.Cold Spring Harbor perspectives in biology · 2012Review
- Fgf and Hh signalling act on a symmetrical pre-pattern to specify anterior and posterior identity in the zebrafish otic placode and vesicle.Development (Cambridge, England) · 2011Article
- Pax2 and Pea3 synergize to activate a novel regulatory enhancer for spalt4 in the developing ear.Developmental biology · 2010Article
- Ascorbic acid reverses valproic acid-induced inhibition of hoxa2 and maintains glutathione homeostasis in mouse embryos in culture.Cellular and molecular neurobiology · 2010Article
- FGF signaling controls caudal hindbrain specification through Ras-ERK1/2 pathway.BMC developmental biology · 2009Article
- Model organisms inform the search for the genes and developmental pathology underlying malformations of the human hindbrain.Seminars in pediatric neurology · 2009Review
- Boundary cells regulate a switch in the expression of FGF3 in hindbrain rhombomeres.BMC developmental biology · 2009Article
- Analysis of Lrrn1 expression and its relationship to neuromeric boundaries during chick neural development.Neural development · 2007Article
- Fgf3 is required for dorsal patterning and morphogenesis of the inner ear epithelium.Development (Cambridge, England) · 2007Article
- Segmentation in staged human embryos: the occipitocervical region revisited.Journal of anatomy · 2003Article
- Fgfr1 regulates patterning of the pharyngeal region.Genes & development · 2003Article
- Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The gene Fgf-3 is expressed in rhombomeres 5 and 6 of the hindbrain and has been functionally implicated in otic development. We describe new sites of expression of this gene in mouse embryos in the forebrain, the midbrain-hindbrain junction region, rhombomere boundaries, a cranial surface ectodermal domain that includes the otic placode, and in the most recently formed somite. In the early hindbrain, high levels of Fgf-3 transcripts are present in rhombomere 4. The surface ectodermal domain at first (day 8 1/2) extends laterally from rhombomeres 4 and 5 (prorhombomere B), in which neuroepithelial levels of expression are highest, to the second pharyngeal arch ventrally; at day 9, when the region of highest level of neuroepithelial Fgf-3 expression is in rhombomeres 5 and 6, the dorsal origin of the surface ectodermal domain is also at this level, extending obliquely to the otic placode and the second arch. The initially high level of Fgf-3 transcripts in the otic placode is downregulated as the placode invaginates to form the otic pit. Fgf-3 is a good marker for the epithelium of pharyngeal arches 2 and 3, and our in situ hybridization results confirm the dual identity of the apparently fused first and second arches in some retinoic acid-exposed embryos, and the fusion of the first arch with the maxillary region in others. Correlation between Fgf-3 expression and morphological pattern in craniofacial tissues of normal and retinoic acid-exposed embryos indicates that prorhombomere B, the second arch and the otic ectoderm represent a cranial segment whose structural integrity is maintained when hindbrain morphology and pharyngeal arch morphology are altered. Comparison of normal Fgf-3 expression domains with those of Fgf-4 and with the phenotype of Fgf-3-deficient mutant embryos suggests that there is some functional redundancy between Fgf-3 and Fgf-4 in otic induction and second arch development.
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