ArticleThe Journal of physiology1996
Ca2+ responses to ATP via purinoceptors in the early embryonic chick retina.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 78 citations in OpenAlex.
- Cell cycle regulation by ADP and IGF-1 in cultured late developing glia progenitors of the avian retina.Purinergic signalling · 2025Article
- The Healthy and Diseased Retina Seen through Neuron-Glia Interactions.International journal of molecular sciences · 2024Review
- Purinergic signaling in the retina: From development to disease.Brain research bulletin · 2019Review
- Short- and long-term (trophic) purinergic signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Purinergic signalling during development and ageing.Purinergic signalling · 2015Review
- ATP induces the death of developing avian retinal neurons in culture via activation of P2X7 and glutamate receptors.Purinergic signalling · 2013Article
- Purinergic signaling promotes proliferation of adult mouse subventricular zone cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Ion channel activities in neural stem cells of the neuroepithelium.Stem cells international · 2012Article
- Purinergic signaling in embryonic and stem cell development.Cellular and molecular life sciences : CMLS · 2011Review
- Long-term (trophic) purinergic signalling: purinoceptors control cell proliferation, differentiation and death.Cell death & disease · 2010Review
- Opposing effects of P2X(7) and P2Y purine/pyrimidine-preferring receptors on proliferation of astrocytes induced by fibroblast growth factor-2: implications for CNS development, injury, and repair.Journal of neuroscience research · 2008Article
- Müller glia as an active compartment modulating nervous activity in the vertebrate retina: neurotransmitters and trophic factors.Neurochemical research · 2008Review
- Dynamic ATP signalling and neural development.The Journal of physiology · 2008Review
- Nucleotide signaling in nervous system development.Pflugers Archiv : European journal of physiology · 2006Review
- Purinergic and muscarinic modulation of the cell cycle and calcium signaling in the chick retinal ventricular zone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The action of adenosine triphosphate on cytoplasmic Ca2+ concentration ([Ca2+]i) was studied in the retinal cell of early embryonic chicks with fura-2 fluorescence measurements. The fluorescence was measured from the whole neural retina dissected from chick embryos at embryonic day three (E3). 2. Bath application of ATP (> or = 30 microM; EC50, 128 microM) raised [Ca2+]i by the release of Ca2+ from intracellular Ca2+ stores, since the Ca2+ response to ATP occurred even in a Ca(2+)-free medium. 3. The Ca2+ response to ATP was mediated by P2U purinoceptors. An agonist for P2U purinoceptors, uridine triphosphate (UTP), evoked Ca2+ rises more potently (> or = 3 microM; EC50, 24 microM) than ATP. Agonists for P2X purinoceptors, alpha, beta-methylene ATP and beta, gamma-methylene ATP, or an agonist for P2Y purinoceptors, 2-methylthio ATP (500 microM each), caused no Ca2+ response. Suramin (100 microM) and Reactive Blue 2 (50 microM) almost completely blocked the Ca2+, responses to 500 microM ATP and 200 microM UTP. 4. The developmental profile of the Ca2+ response to ATP was studied from E3 to E13. The Ca2+ response to ATP was largest at E3, drastically declined towards E8 and decreased further until E11-13. 5. These results suggest that the Ca2+ mobilization by ATP via P2U purinoceptors is characteristic of early embryonic retinal cells.
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