ArticleBritish journal of pharmacology1996
Characterization of Na+ influx mediated by ATP(4-)-activated P2 purinoceptors in PC12 cells.
Article in British journal of pharmacology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 18 citations in OpenAlex.
- Effective targeting of microglial P2X7 following intracerebroventricular delivery of nanobodies and nanobody-encoding AAVs.Frontiers in pharmacology · 2022Article
- Inhibition of ATP-activated current by zinc in dorsal root ganglion neurones of bullfrog.The Journal of physiology · 1997Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Micromolar levels of extracellular ATP increased cytosolic Na+ concentration ([Na+]i) as well as cytosolic Ca2+ concentration ([Ca2+]i) in PC12 cells. 2. Pretreatment of cells with tetrodotoxin, benzamil or thapsigargin did not alter the ATP-induced Na+ influx. 3. Increased extracellular Mg2+ concentration decreased the ATP effect. Furthermore, when the extracellular ATP pool was treated to contain corresponding calculated concentrations of ATP4-, the increase in [Na+]i stayed linked to the ATP4- concentration rather than to the total ATP concentrations in the stimulants. 4. Extracellular ATP does not create nonselective pores as shown by the fact that ethidium bromide does not enter the cells upon ATP stimulation. 5. Among the tested nucleotides, only adenosine 5'-O-(3-thiotriphosphate), 2-methylthio ATP and 2-chloro ATP also caused Na+ influx. 6. Reactive Blue 2 specifically decreased the ATP effect in a concentration-dependent manner. 7. The results suggest that extracellular ATP triggers Na+ influx through a P2 purinoceptor which is activated by ATP4- in PC12 cells.
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