ArticleProceedings of the National Academy of Sciences of the United States of America1996
Trials of the beta model for complex inheritance.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- A first trial of retrospective collaboration for positional cloning in complex inheritance: assay of the cytokine region on chromosome 5 by the consortium on asthma genetics (COAG).Proceedings of the National Academy of Sciences of the United States of America · 2000Trial
- Individual disease risk and multimetric analysis of Crohn disease.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Article
- Pseudoautosomal linkage of Hodgkin disease.American journal of human genetics · 2000Article
- Pseudoautosomal linkage of Hodgkin disease.American journal of human genetics · 1999Article
- Tests and estimates of allelic association in complex inheritance.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Significance levels in complex inheritance.American journal of human genetics · 1998Article
- Immunogenetics of leishmanial and mycobacterial infections: the Belem Family Study.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1997Review
- Comparison of parametric and nonparametric methods to map oligogenes by linkage.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Theoretical advantages of nonparametric logarithm of odds to map polygenic diseases are supported by tests of the beta model that depends on a single logistic parameter and is the only model under which paternal and maternal transmissions to sibs of specified phenotypes are independent. Although it does not precisely describe recurrence risks in monozygous twins, the beta model has greater power to detect family resemblance or linkage than the more general delta model which describes the probability of 0, 1, or 2 alleles identical by descent (ibd) with two parameters. Available data on ibd in sibs are consistent with the beta model, but not with the equally parsimonious but less powerful gamma model that assumes a fixed probability of 1/2 for 1 allele ibd. Additivity of loci on the liability scale is not disproven. A simple equivalence extends the beta model to multipoint analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.