ArticleProceedings of the National Academy of Sciences of the United States of America1996
Induction of nephrogenic mesenchyme by osteogenic protein 1 (bone morphogenetic protein 7).
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 186 citations in OpenAlex.
- Mutual repression between Pax2 and Snail factors regulates the epithelial/mesenchymal state during intermediate mesoderm differentiation.Development (Cambridge, England) · 2025Article
- A re-appraisal of mesenchymal-epithelial transition (MET) in endometrial epithelial remodeling.Cell and tissue research · 2023Article
- The Role Of BMPs in the Regulation of Osteoclasts Resorption and Bone Remodeling: From Experimental Models to Clinical Applications.Frontiers in immunology · 2022Review
- Genome-Wide Association Study of Diabetic Kidney Disease Highlights Biology Involved in Glomerular Basement Membrane Collagen.Journal of the American Society of Nephrology : JASN · 2019Article
- BMP7 plays a critical role in TMEM100-inhibited cell proliferation and apoptosis in mouse metanephric mesenchymal cells in vitro.In vitro cellular & developmental biology. Animal · 2018Article
- Single-tubule RNA-Seq uncovers signaling mechanisms that defend against hyponatremia in SIADH.Kidney international · 2018Article
- Roles and regulation of bone morphogenetic protein-7 in kidney development and diseases.World journal of stem cells · 2016Review
- Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice.International orthopaedics · 2015Article
- Epigenetic unsilencing reverses renal fibrosis.Journal of the American Society of Nephrology : JASN · 2014Article
- The clinical use of bone morphogenetic proteins revisited: a novel biocompatible carrier device OSTEOGROW for bone healing.International orthopaedics · 2014Review
- The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling.Biochemical and biophysical research communications · 2013Article
- Exogenous heparin binds and inhibits bone morphogenetic protein 6 biological activity.International orthopaedics · 2013Article
- Bmp7 maintains undifferentiated kidney progenitor population and determines nephron numbers at birth.PloS one · 2013Article
- Clinicopathological significance of BMP7 expression in esophageal squamous cell carcinoma.Annals of surgical oncology · 2012Article
- Reciprocal induction of simple organogenesis by mouse kidney progenitor cells in three-dimensional co-culture.The American journal of pathology · 2012Article
- Circulating bone morphogenetic protein 1-3 isoform increases renal fibrosis.Journal of the American Society of Nephrology : JASN · 2011Article
- Loss of endogenous bone morphogenetic protein-6 aggravates renal fibrosis.The American journal of pathology · 2011Article
- Article
- Transcriptional control of human antigen R by bone morphogenetic protein.The Journal of biological chemistry · 2010Article
- Trps1 functions downstream of Bmp7 in kidney development.Journal of the American Society of Nephrology : JASN · 2009Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The definitive mammalian kidney forms as the result of reciprocal interactions between the ureteric bud epithelium and metanephric mesenchyme. As osteogenic protein 1 (OP-1/bone morphogenetic protein 7), a member of the TGF-beta superfamily of proteins, is expressed predominantly in the kidney, we examined its involvement during metanephric induction and kidney differentiation. We found that OP-1 mRNA is expressed in the ureteric bud epithelium before mesenchymal condensation and is subsequently seen in the condensing mesenchyme and during glomerulogenesis. Mouse kidney metanephric rudiments cultured without ureteric bud epithelium failed to undergo mesenchymal condensation and further epithelialization, while exogenously added recombinant OP-1 was able to substitute for ureteric bud epithelium in restoring the induction of metanephric mesenchyme. This OP-1-induced nephrogenic mesenchyme differentiation follows a developmental pattern similar to that observed in the presence of the spinal cord, a metanephric inducer. Blocking OP-1 activity using either neutralizing antibodies or antisense oligonucleotides in mouse embryonic day 11.5 mesenchyme, cultured in the presence of metanephric inducers or in intact embryonic day 11.5 kidney rudiment, greatly reduced metanephric differentiation. These results demonstrate that OP-1 is required for metanephric mesenchyme differentiation and plays a functional role during kidney development.
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