ArticleProceedings of the National Academy of Sciences of the United States of America1996
Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 139 citations in OpenAlex.
- Small Molecule-Induced Pancreatic β-Like Cell Development: Mechanistic Approaches and Available Strategies.International journal of molecular sciences · 2020Review
- Article
- Metformin Restrains Pancreatic Duodenal Homeobox-1 (PDX-1) Function by Inhibiting ERK Signaling in Pancreatic Ductal Adenocarcinoma.Current molecular medicine · 2016Article
- Grg3/TLE3 and Grg1/TLE1 induce monohormonal pancreatic β-cells while repressing α-cell functions.Diabetes · 2014Article
- Generating NMR chemical shift assignments of intrinsically disordered proteins using carbon-detected NMR methods.Analytical biochemistry · 2014Article
- Vertically integrated translational studies of PDX1 as a therapeutic target for pancreatic cancer via a novel bifunctional RNAi platform.Cancer gene therapy · 2014Review
- Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.Frontiers in physiology · 2014Review
- Thermodynamic and structural determinants of differential Pdx1 binding to elements from the insulin and IAPP promoters.Journal of molecular biology · 2013Article
- The role of single-cell analyses in understanding cell lineage commitment.Biotechnology journal · 2013Review
- Intestinal Pdx1 mediates nutrient metabolism gene networks and maternal expression is essential for perinatal growth in mice.Biochemical and biophysical research communications · 2012Article
- PDX1 regulation of FABP1 and novel target genes in human intestinal epithelial Caco-2 cells.Biochemical and biophysical research communications · 2012Article
- Expression profiling identifies novel gene targets and functions for Pdx1 in the duodenum of mature mice.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
- PDX-1 is a therapeutic target for pancreatic cancer, insulinoma and islet neoplasia using a novel RNA interference platform.PloS one · 2012Article
- The hypofunctional effect of P335L single nucleotide polymorphism on SSTR5 function.World journal of surgery · 2011Article
- New role for alpha cells as a source for new beta cells.Journal of diabetes investigation · 2011Article
- Novel monoclonal antibodies against Pdx1 reveal feedback regulation of Pdx1 protein levels.European journal of histochemistry : EJH · 2010Article
- Pdx1 inactivation restricted to the intestinal epithelium in mice alters duodenal gene expression in enterocytes and enteroendocrine cells.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- ParaHox genes in pancreatic cell cultures: effects on the insulin promoter regulation.International journal of biological sciences · 2008Article
- Relative contribution of PDX-1, MafA and E47/beta2 to the regulation of the human insulin promoter.The Biochemical journal · 2005Article
- Transcriptional networks controlling pancreatic development and beta cell function.Diabetologia · 2004Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insulin promoter factor 1 (IPF1), a member of the homeodomain protein family, serves an early role in pancreas formation, as evidenced by the lack of pancreas formation in mice carrying a targeted disruption of the IPF1 gene [Jonsson, J., Carlsson, L., Edlund, T. & Edlund, H. (1994) Nature (London) 371, 606-609]. In adults, IPF1 expression is restricted to the beta-cells in the islets of Langerhans. We report here that IPF1 induces expression of a subset of beta-cell-specific genes (insulin and islet amyloid polypeptide) when ectopically expressed in clones of transformed pancreatic islet alpha-cells. In contrast, expression of IPF1 in rat embryo fibroblasts factor failed to induce insulin and islet amyloid polypeptide expression. This is most likely due to the lack of at least one other essential insulin gene transcription factor, the basic helix-loop-helix protein Beta 2/NeuroD, which is expressed in both alpha- and beta-cells. We conclude that IPF1 is a potent transcriptional activator of endogenous insulin genes in non-beta islet cells, which suggests an important role of IPF1 in beta-cell maturation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.