ArticleProceedings of the National Academy of Sciences of the United States of America1996
UV irradiation-induced apoptosis leads to activation of a 36-kDa myelin basic protein kinase in HL-60 cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 41 citations in OpenAlex.
- Metabolic Recycling Enhances Proliferation in MYC-Transformed Lymphoma B Cells.Advanced biology · 2023Article
- Mst1: Function and Mechanism in Brain and Myocardial Ischemia Reperfusion Injury.Current neuropharmacology · 2018Review
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- Whole-genome DNA methylation characteristics in pediatric precursor B cell acute lymphoblastic leukemia (BCP ALL).PloS one · 2017Article
- Regulation of mammalian Ste20 (Mst) kinases.Trends in biochemical sciences · 2015Review
- Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1.International journal of cardiology · 2013Article
- MST1 promotes apoptosis through phosphorylation of histone H2AX.The Journal of biological chemistry · 2010Article
- Polymorphisms in innate immunity genes and risk of childhood leukemia.Human immunology · 2010Article
- Caspases and kinases in a death grip.Cell · 2009Review
- The human WW45 protein enhances MST1-mediated apoptosis in vivo.International journal of molecular medicine · 2009Article
- Stress-induced corneal epithelial apoptosis mediated by K+ channel activation.Progress in retinal and eye research · 2006Review
- Activation of sterile20-like kinase 1 in proteasome inhibitor bortezomib-induced apoptosis in oncogenic K-ras-transformed cells.Cancer research · 2006Article
- Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Article
- Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
UV irradiation induces apoptosis (or programmed cell death) in HL-60 promyelocytic leukemia cells within 3 h. UV-induced apoptosis is accompanied by activation of a 36-kDa myelin basic protein kinase (p36 MBP kinase). This kinase is also activated by okadaic acid and retinoic acid-induced apoptosis. Irrespective of the inducing agent, p36 MBP kinase activation is restricted to the subpopulation of cells actually undergoing apoptosis. Activation of p36 MBP kinase occurs in enucleated cytoplasts, indicating no requirement for a nucleus or fragmented DNA in signaling. We also demonstrate the activation of p36 kinase in tumor necrosis factor-alpha- and serum starvation-induced cell death using the human prostatic tumor cell line LNCap and NIH 3T3 fibroblasts, respectively. We postulate that p36 MBP kinase is a common component in diverse signaling pathways leading to apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.