ArticleJapanese journal of cancer research : Gann1996
E-cadherin gene mutations in signet ring cell carcinoma of the stomach.
Article in Japanese journal of cancer research : Gann, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 138 citations in OpenAlex.
- Identification of Gene Signatures Differentiating Cancer from Normal Tissues Across Histological Classifications of Gastric Adenocarcinoma via Machine Learning Methods.Biochemical genetics · 2026Article
- Molecular pathological approach to cancer epigenomics and its clinical application.Pathology international · 2024Review
- Article
- Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features.Nature communications · 2023Article
- Signet ring cell cancer of stomach and gastro-esophageal junction: molecular alterations, stage-stratified treatment approaches, and future challenges.Langenbeck's archives of surgery · 2022Review
- Review
- Long-term model of colitis-associated colorectal cancer suggests tumor spread mechanism and nature of cancer stem cells.Oncology letters · 2021Article
- Immunohistochemical analysis of beta-catenin, E-cadherin and p53 in canine gastrointestinal epithelial tumors.The Journal of veterinary medical science · 2020Article
- State of the art for gastric signet ring cell carcinoma: from classification, prognosis, and genomic characteristics to specified treatments.Cancer management and research · 2019Review
- Loss of E-Cadherin-Dependent Cell-Cell Adhesion and the Development and Progression of Cancer.Cold Spring Harbor perspectives in biology · 2018Review
- Signal transduction growth factors: the effective governance of transcription and cellular adhesion in cancer invasion.Oncotarget · 2017Review
- Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions.Journal of clinical medicine · 2016Review
- The network of epithelial-mesenchymal transition: potential new targets for tumor resistance.Journal of cancer research and clinical oncology · 2015Review
- Article
- Deciphering Seed Sequence Based Off-Target Effects in a Large-Scale RNAi Reporter Screen for E-Cadherin Expression.PloS one · 2015Article
- Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes in gastric and colorectal cancers with high microsatellite instability.Pathology oncology research : POR · 2015Article
- Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer.Oncology letters · 2014Article
- Investigation of β-catenin and E-cadherin expression in Dukes B2 stage colorectal cancer with tissue microarray method. Is it a marker of metastatic potential in rectal cancer?Pathology oncology research : POR · 2012Article
- The basics of epithelial-mesenchymal transition.The Journal of clinical investigation · 2009Review
- Regulation of metastasis in colorectal adenocarcinoma: a collision between development and tumor biology.Surgery · 2008Review
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To clarify the significance of E-cadherin gene alterations in the development of diffuse-type adenocarcinoma of the stomach, we analyzed mutations of the E-cadherin gene using the polymerase chain reaction single-strand conformation polymorphism (PCR-SSCP) method followed by direct sequencing. Twenty-two signet ring cell carcinomas of the stomach (10 intramucosal and 12 advanced cancers) were examined. Genomic DNA was extracted separately from cancerous and non-cancerous tissues and PCR-SSCP analysis was performed on exons 5 to 9 and the adjacent 30- to 40-base-pair intron sequences of the E-cadherin gene. Mobility shifts were found in 2 of the 10 intramucosal cancers. In 2 of the 12 advanced cancers, abnormalities of the E-cadherin gene were observed in intramucosal lesions as well as in deeply invaded areas. These results indicated that E-cadherin gene mutations are an early event in the development of signet ring cell carcinoma of the stomach. Direct sequencing revealed that the locations of mutations of the E-cadherin gene included the branch point sequence in the intron which is responsible for RNA splicing. Reverse transcriptase-PCR demonstrated aberrant RNA splicing in a case with a branch point mutation, suggesting that branch point mutations play an important role in functional modifications of E-cadherin in signet ring cell carcinoma of the stomach.
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