ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Rapid, active hair bundle movements in hair cells from the bullfrog's sacculus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
82 citing papers in PubMed, 167 citations in OpenAlex.
- Article
- Criticality and chaos in auditory and vestibular sensing.Scientific reports · 2024Article
- Review of chaos in hair-cell dynamics.Frontiers in neurology · 2024Review
- Coupling between the Stereocilia of Rat Sensory Inner-Hair-Cell Hair Bundles Is Weak, Shaping Their Sensitivity to Stimulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Vestibular Drop Attacks and Meniere's Disease as Results of Otolithic Membrane Damage-A Numerical Model.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Complex dynamics of hair bundle of auditory nervous system (II): forced oscillations related to two cases of steady state.Cognitive neurodynamics · 2022Article
- Complex dynamics of hair bundle of auditory nervous system (I): spontaneous oscillations and two cases of steady states.Cognitive neurodynamics · 2022Article
- Article
- Chaotic Dynamics Enhance the Sensitivity of Inner Ear Hair Cells.Scientific reports · 2019Article
- Active Biomechanics of Sensory Hair Bundles.Cold Spring Harbor perspectives in medicine · 2019Review
- The Development of Cooperative Channels Explains the Maturation of Hair Cell's Mechanotransduction.Biophysical journal · 2019Article
- Chaotic Dynamics of Inner Ear Hair Cells.Scientific reports · 2018Article
- Article
- Lipid bilayer mediates ion-channel cooperativity in a model of hair-cell mechanotransduction.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- High-order synchronization of hair cell bundles.Scientific reports · 2016Article
- Frequency locking in auditory hair cells: Distinguishing between additive and parametric forcing.Europhysics letters · 2016Article
- Voltage-Mediated Control of Spontaneous Bundle Oscillations in Saccular Hair Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Mechanical amplification exhibited by quiescent saccular hair bundles.Biophysical journal · 2015Article
- Article
- The physiology of mechanoelectrical transduction channels in hearing.Physiological reviews · 2014Review
22 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Hair bundles, the mechanically sensitive organelles of hair cells in the auditory and vestibular systems, are elastic structures that are deflected by sound or acceleration. To examine rapid mechanical events associated with mechanoelectrical transduction, we stimulated individual hair bundles with flexible glass fibers and measured their responses with a temporal resolution of 400 microsec. When a hair bundle from the bullfrog's sacculus was abruptly deflected in the positive direction, the bundle's motion in the direction of stimulation was interrupted within the initial few milliseconds by an active movement, or twitch. This response was biphasic, with an initial component in the direction of the stimulus and a second component in the opposite direction. The amplitude and duration of the twitch depended on the bundle's initial position and the size and rise time of the stimulus; the twitch was largest over the range of bundle deflections in which transduction was most sensitive. Under displacement clamp conditions, in which a hair bundle's position was changed and then held constant with negative feedback, the twitch manifested itself as a biphasic force exerted by the bundle. Some hair bundles produced twitches in response to negatively directed stimuli, exhibited stimulus-evoked damped oscillations, or twitched spontaneously. The hair bundle's ability to perform work against an external load and to oscillate in response to stimulation indicates that the bundle could supply feedback for mechanical amplification in vertebrate auditory organs.
Indexed as
Identifiers
8795619PMC6578960W2116150400What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.