ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1996
Reduced growth cone motility in cultured neurons from Drosophila memory mutants with a defective cAMP cascade.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Postsynaptic cAMP signalling regulates the antagonistic balance ofDevelopment (Cambridge, England) · 2020Article
- Cyclic nucleotide signaling is required during synaptic refinement at the Drosophila neuromuscular junction.Developmental neurobiology · 2017Article
- Role of protein kinase A in regulating mitochondrial function and neuronal development: implications to neurodegenerative diseases.Reviews in the neurosciences · 2015Review
- Global and local missions of cAMP signaling in neural plasticity, learning, and memory.Frontiers in pharmacology · 2015Review
- The role of cAMP in synaptic homeostasis in response to environmental temperature challenges and hyperexcitability mutations.Frontiers in cellular neuroscience · 2015Article
- Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Increased dynamin-1 and -2 protein expression in the aged gerbil hippocampus.Cellular and molecular neurobiology · 2014Article
- Article
- Suppression of inhibitory GABAergic transmission by cAMP signaling pathway: alterations in learning and memory mutants.The European journal of neuroscience · 2013Article
- Cyclic adenosine monophosphate metabolism in synaptic growth, strength, and precision: neural and behavioral phenotype-specific counterbalancing effects between dnc phosphodiesterase and rut adenylyl cyclase mutations.Journal of neurogenetics · 2012Article
- Neuroplasticity signaling pathways linked to the pathophysiology of schizophrenia.Neuroscience and biobehavioral reviews · 2011Review
- Orchestration of stepwise synaptic growth by K+ and Ca2+ channels in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Cell specific dopamine modulation of the transient potassium current in the pyloric network by the canonical D1 receptor signal transduction cascade.Journal of neurophysiology · 2010Article
- The cyclic AMP phenotype of fragile X and autism.Neuroscience and biobehavioral reviews · 2008Review
- Imaging second messenger dynamics in developing neural circuits.Developmental neurobiology · 2008Review
- The DISC locus in psychiatric illness.Molecular psychiatry · 2008Review
- Temperature-dependent developmental plasticity of Drosophila neurons: cell-autonomous roles of membrane excitability, Ca2+ influx, and cAMP signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Drosophila as a genetic and cellular model for studies on axonal growth.Neural development · 2007Review
- NeuronMetrics: software for semi-automated processing of cultured neuron images.Brain research · 2007Article
- Phenotypes of Drosophila brain neurons in primary culture reveal a role for fascin in neurite shape and trajectory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila memory mutants dunce (dnc) and rutabaga (rut) are known to have altered intracellular cAMP levels, nerve terminal growth, and plasticity of synaptic transmission. Because the growth cone is responsible for neurite outgrowth and synaptogenesis, video microscopy was used to examine growth cone morphology and behavior of mutant neurons in larval CNS cultures. We found that growth cone exploratory movement was nearly arrested by both mutations, even though they change cAMP levels in opposite directions. The dnc phenotype could be mimicked by normal neurons when perfused with dibutyryl cAMP (db-cAMP) or forskolin. In contrast, rut growth cones became active when perfused with db-cAMP. Furthermore, motility was also restored by counterbalancing the effects of the two genes in double mutants, indicating that dynamic control of growth cone motility in developing Drosophila neurons requires optimal cAMP levels within an operational range. These findings represent the first demonstration of altered growth cone properties in learning and memory mutants and establish in a natural setting the role of cAMP in growth cone motility and neuronal plasticity.
Indexed as
Identifiers
8795615PMC6578966What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.