ArticleThe Journal of cell biology1996
Talin and vinculin play distinct roles in filopodial motility in the neuronal growth cone.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 103 citations in OpenAlex.
- Integrin-Talin axis regulates mechanosensory presynaptic development and behavioral habituation to mechanical stimulation.G3 (Bethesda, Md.) · 2026Article
- Adhesion-clutch between DCC and netrin-1 mediates netrin-1-induced axonal haptotaxis.Frontiers in molecular neuroscience · 2024Article
- Alzheimer's-Associated Upregulation of Mitochondria-Associated ER Membranes After Traumatic Brain Injury.Cellular and molecular neurobiology · 2023Article
- Förster resonance energy transfer efficiency of the vinculin tension sensor in cultured primary cortical neuronal growth cones.Neurophotonics · 2022Article
- Mechanosensitive axon outgrowth mediated by L1-laminin clutch interface.Biophysical journal · 2021Article
- Vinculin-mediated axon growth requires interaction with actin but not talin in mouse neocortical neurons.Cellular and molecular life sciences : CMLS · 2021Article
- The Influence of the Surface Topographical Cues of Biomaterials on Nerve Cells in Peripheral Nerve Regeneration: A Review.Stem cells international · 2021Review
- Different Vinculin Binding Sites Use the Same Mechanism to Regulate Directional Force Transduction.Biophysical journal · 2020Article
- Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion.Nature communications · 2019Article
- Involvement of advillin in somatosensory neuron subtype-specific axon regeneration and neuropathic pain.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts.Chemical reviews · 2018Review
- Quantifying Filopodia in Cultured Astrocytes by an Algorithm.Neurochemical research · 2017Article
- Regulation of Intracellular Structural Tension by Talin in the Axon Growth and Regeneration.Molecular neurobiology · 2016Article
- Mechanochemical regulation of growth cone motility.Frontiers in cellular neuroscience · 2015Review
- Molecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions.BioMed research international · 2015Review
- Actin dynamics in growth cone motility and navigation.Journal of neurochemistry · 2014Review
- The unconventional secretion of stress-inducible protein 1 by a heterogeneous population of extracellular vesicles.Cellular and molecular life sciences : CMLS · 2013Article
- Chromophore-assisted laser inactivation in neural development.Neuroscience bulletin · 2012Review
- Growth cone travel in space and time: the cellular ensemble of cytoskeleton, adhesion, and membrane.Neuron · 2012Review
- Bidirectional remodeling of β1-integrin adhesions during chemotropic regulation of nerve growth.BMC biology · 2011Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Filopodial motility is critical for many biological processes, particularly for axon guidance. This motility is based on altering the F-actin-based cytoskeleton, but the mechanisms of how this occurs and the actin-associated proteins that function in this process remain unclear. We investigated two of these proteins found in filopodia, talin and vinculin, by inactivating them in subregions of chick dorsal root ganglia neuronal growth cones and by observing subsequent behavior by video-enhanced microscopy and quantitative morphometry. Microscale chromophore-assisted laser inactivation of talin resulted in the temporary cessation of filopodial extension and retraction. Inactivation of vinculin caused an increased incidence of filopodial bending and buckling within the laser spot but had no effect on extension or retraction. These findings show that talin acts in filopodial motility and may couple both extension and retraction to actin dynamics. They also suggest that vinculin is not required for filopodial extension and retraction but plays a role in the structural integrity of filopodia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.