ArticleThe Journal of cell biology1996
Two muscle-specific LIM proteins in Drosophila.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- Cystatin antibodies interfere with ovary development in Haemaphysalis doenitzi (Acari: Ixodidae).PLoS neglected tropical diseases · 2025Article
- A new ferritin SjFer0 affecting the growth and development of Schistosoma japonicum.Parasites & vectors · 2022Article
- Drosophila melanogaster muscle LIM protein and alpha-actinin function together to stabilize muscle cytoarchitecture: a potential role for Mlp84B in actin-crosslinking.Cytoskeleton (Hoboken, N.J.) · 2013Article
- FGF signaling induces mesoderm in the hemichordate Saccoglossus kowalevskii.Development (Cambridge, England) · 2013Article
- Phosphorylation of the Drosophila melanogaster RNA-binding protein HOW by MAPK/ERK enhances its dimerization and activity.PLoS genetics · 2012Article
- Article
- Deletion of Drosophila muscle LIM protein decreases flight muscle stiffness and power generation.American journal of physiology. Cell physiology · 2011Article
- Tissue remodeling: a mating-induced differentiation program for the Drosophila oviduct.BMC developmental biology · 2008Article
- How insects survive the cold: molecular mechanisms-a review.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2008Review
- Proteome response to the panneural expression of human wild-type alpha-synuclein: a Drosophila model of Parkinson's disease.Journal of proteome research · 2008Article
- Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease.Molecular & cellular proteomics : MCP · 2008Article
- Actin bundling via LIM domains.Plant signaling & behavior · 2008Article
- Tobacco WLIM1 is a novel F-actin binding protein involved in actin cytoskeleton remodeling.The Plant cell · 2006Article
- Article
- Molecular genetics of the Alhambra (Drosophila AF10) complex locus of Drosophila.Molecular genetics and genomics : MGG · 2004Article
- Caste- and development-associated gene expression in a lower termite.Genome biology · 2003Article
- Activation of the JNK pathway during dorsal closure in Drosophila requires the mixed lineage kinase, slipper.Genes & development · 2002Article
- A novel muscle LIM-only protein is generated from the paxillin gene locus in Drosophila.EMBO reports · 2001Article
- Fine mapping of the alpha-actinin binding site within cysteine-rich protein.The Biochemical journal · 2000Article
- Muscle LIM proteins are associated with muscle sarcomeres and require dMEF2 for their expression during Drosophila myogenesis.Molecular biology of the cell · 1999Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The LIM domain defines a zinc-binding motif found in a growing number of eukaryotic proteins that regulate cell growth and differentiation during development. Members of the cysteine-rich protein (CRP) family of LIM proteins have been implicated in muscle differentiation in vertebrates. Here we report the identification and characterization of cDNA clones encoding two members of the CRP family in Drosophila, referred to as muscle LIM proteins (Mlp). Mlp60A encodes a protein with a single LIM domain linked to a glycine-rich region. Mlp84B encodes a protein with five tandem LIM-glycine modules. In the embryo, Mlp gene expression is spatially restricted to somatic, visceral, and pharyngeal muscles. Within the somatic musculature, Mlp84B transcripts are enriched at the terminal ends of muscle fibers, whereas Mlp60A transcripts are found throughout the muscle fibers. The distributions of the Mlp60A and Mlp84B proteins mirror their respective mRNA localizations, with Mlp84B enrichment occurring at sites of muscle attachment. Northern blot analysis revealed that Mlp gene expression is developmentally regulated, showing a biphasic pattern over the course of the Drosophila life cycle. Peaks of expression occur late in embryogenesis and during metamorphosis, when the musculature is differentiating. Drosophila Mlp60A and Mlp84B, like vertebrate members of the CRP family, have the ability to associate with the actin cytoskeleton when expressed in rat fibroblast cells. The temporal expression and spatial distribution of muscle LIM proteins in Drosophila are consistent with a role for Mlps in myogenesis, late in the differentiation pathway.
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