ArticleThe Journal of cell biology1996
Centromere and telomere movements during early meiotic prophase of mouse and man are associated with the onset of chromosome pairing.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers.
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Who cites it
181 citing papers in PubMed, 438 citations in OpenAlex.
- NEMP1 organizes the meiotic telomere-LINC interface to control chromosome movement and telomere integrity.bioRxiv : the preprint server for biology · 2026Article
- Genome-wide crossover analysis in the holocentric pantry moth reveals strong crossover assurance and interference during spermatogenesis.Genome research · 2026Article
- Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline.Science advances · 2025Article
- CENP-A is diluted during bovine spermatogenesis and is maintained at internally positioned centromere clusters in mature bull sperm.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025Article
- Rewiring for movements in meiotic prophase: regulators, roles, and evolutionary pathways.Current opinion in genetics & development · 2025Review
- Article
- The conserved ATPase PCH-2 controls the number and distribution of crossovers by antagonizing their formation inbioRxiv : the preprint server for biology · 2024Article
- FBXO47 regulates centromere pairing as key component of centromeric SCF E3 ligase in mouse spermatocytes.Communications biology · 2024Article
- Formation and resolution of meiotic chromosome entanglements and interlocks.Journal of cell science · 2024Review
- Agent-based modeling of nuclear chromosome ensembles identifies determinants of homolog pairing during meiosis.PLoS computational biology · 2024Article
- Agent-based modeling of nuclear chromosome ensemble identifies determinants of homolog pairing during meiosis.bioRxiv : the preprint server for biology · 2024Article
- ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis.Communications biology · 2023Article
- The fine-scale recombination rate variation and associations with genomic features in a butterfly.Genome research · 2023Article
- Loss of SUN1 function in spermatocytes disrupts the attachment of telomeres to the nuclear envelope and contributes to non-obstructive azoospermia in humans.Human genetics · 2023Article
- Review
- MJL-1 is a nuclear envelope protein required for homologous chromosome pairing and regulation of synapsis during meiosis inScience advances · 2023Article
- RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits.Protein & cell · 2023Article
- Article
- Time to match; when do homologous chromosomes become closer?Chromosoma · 2022Article
- Mouse oocytes carrying metacentric Robertsonian chromosomes have fewer crossover sites and higher aneuploidy rates than oocytes carrying acrocentric chromosomes alone.Scientific reports · 2022Article
121 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The preconditions and early steps of meiotic chromosome pairing were studied by fluorescence in situ hybridization (FISH) with chromosome-specific DNA probes to mouse and human testis tissue sections. Premeiotic pairing of homologous chromosomes was not detected in spermatogonia of the two species. FISH with centromere- and telomere-specific DNA probes in combination with immunostaining (IS) of synaptonemal complex (SC) proteins to testis sections of prepuberal mice at days 4-12 post partum was performed to study sequentially the meiotic pairing process. Movements of centromeres and then telomeres to the nuclear envelope, and of telomeres along the nuclear envelope leading to the formation of a chromosomal bouquet were detected during mouse prophase. At the bouquet stage, pairing of a mouse chromosome-8-specific probe was observed. SC-IS and simultaneous telomere FISH revealed that axial element proteins appear as large aggregates in mouse meiocytes when telomeres are attached to the nuclear envelope. Axial element formation initiates during tight telomere clustering and transverse filament-IS indicated the initiation of synapsis during this stage. Comparison of telomere and centromere distribution patterns of mouse and human meiocytes revealed movements of centromeres and then telomeres to the nuclear envelope and subsequent bouquet formation as conserved motifs of the pairing process. Chromosome painting in human spermatogonia revealed compacted, largely mutually exclusive chromosome territories. The territories developed into long, thin threads at the onset of meiotic prophase. Based on these results a unified model of the pairing process is proposed.
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